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神经心理评估的新进展：认知功能与脑淀粉样蛋白沉积的关系
New advances in neuropsychological assessment: the relationship between cognitive function and brain amyloid deposition
- 重庆医科大学学报 2021年46卷第11期 页码：1287-1290
- 作者机构：
上海交通大学附属第六人民医院老年病科，上海 200233
- 作者简介：
[ "黄艳露，Email：hyl163663@163.com，研究方向：认知障碍的评估与诊断。" ]
郭起浩，教授，主任医师，博士，博导，上海交通大学附属第六人民医院老年医学科主任。中华医学会老年医学分会老年神经病学组委员，上海市医师协会老年医学科医师分会副会长。已发表SCI论文140余篇、中文核心期刊论文与综述230多篇。目前在研课题6项，出版专著3本、译著2本，参编专著12本。长期致力于认知障碍临床前预测、早期精准诊断、全程干预研究。Email：qhguo@sjtu.edu.cn。
- 基金信息：国家重点研发计划资助项目(2016YFC1306305;2018YFE0203600)
DOI：10.13406/j.cnki.cyxb.002921
中图分类号： R74纸质出版日期：2021-11-28，
收稿日期：2021-07-27，
扫 描 看 全 文
黄艳露, 郭起浩. 神经心理评估的新进展：认知功能与脑淀粉样蛋白沉积的关系[J]. 重庆医科大学学报, 2021,46(11):1287-1290.
Yanlu Huang, Qihao Guo. New advances in neuropsychological assessment: the relationship between cognitive function and brain amyloid deposition[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1287-1290.
黄艳露, 郭起浩. 神经心理评估的新进展：认知功能与脑淀粉样蛋白沉积的关系[J]. 重庆医科大学学报, 2021,46(11):1287-1290. DOI： 10.13406/j.cnki.cyxb.002921.
Yanlu Huang, Qihao Guo. New advances in neuropsychological assessment: the relationship between cognitive function and brain amyloid deposition[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1287-1290. DOI： 10.13406/j.cnki.cyxb.002921.
摘要
阿尔茨海默病（Alzheimer's disease，AD）是一种退行性疾病。在早期阶段，AD的特征是大脑中β淀粉样蛋白（β amyloid，Aβ）和tau蛋白的聚集和记忆力减退。本文总结了脑内Aβ与认知功能的关系，对当前Aβ如何影响认知功能（记忆、执行、语言）的研究进行了综述，同时对今后研究趋势进行展望，为Aβ沉积的识别提供新思路。
Abstract
Alzheimer's disease (AD) is a kind of degenerative disease. In the early stage
AD is characterized by the aggregation of β amyloid (Aβ) and tau proteins in the brain and memory loss. This paper summarizes the relationship between Aβ and cognitive function of the brain
reviews current research on how Aβ affects cognitive function (memory
execution and language)
and also provides an outlook on future research trends to provide new ideas for the identification of Aβ deposition.
关键词
阿尔茨海默病β淀粉样蛋白认知功能
Keywords
Alzheimer's diseaseβ amyloidcognitive function
references
Liu YH, Wang J, Li QX, et al. Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer's disease[J]. Sci Adv, 2021, 7(1):eabb0457.
Aizenstein HJ, Nebes RD, Saxton JA, et al. Frequent amyloid deposition without significant cognitive impairment among the elderly[J]. Arch Neurol, 2008, 65(11):1509-1517.
Rentz DM, Amariglio RE, Becker JA, et al. Face-name associative memory performance is related to amyloid burden in normal elderly[J]. Neuropsychologia, 2011, 49(9):2776-2783.
Doré V, Villemagne VL, Bourgeat P, et al. Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease[J]. JAMA Neurol, 2013, 70(7):903-911.
Chételat G, Villemagne VL, Pike KE, et al. Independent contribution of temporal beta-amyloid deposition to memory decline in the predementia phase of Alzheimer's disease[J]. Brain, 2011, 134(Pt 3):798-807.
Amariglio RE, Becker JA, Carmasin J, et al. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals[J]. Neuropsychologia, 2012, 50(12):2880-2886.
Hedden T, Oh H, Younger AP, et al. Meta-analysis of amyloidcognition relations in cognitively normal older adults[J]. Neurology, 2013, 80(14):1341-1348.
Villemagne VL, Burnham S, Bourgeat P, et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study[J]. Lancet Neurol, 2013, 12(4):357-367.
Baker JE, Lim YY, Pietrzak RH, et al. Cognitive impairment and decline in cognitively normal older adults with high amyloid-β: a Metaanalysis[J]. Alzheimers Dement(Amst), 2016, 6:108-121.
Vogel JW, Varga Doležalová M, La Joie R, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly[J]. Neurology, 2017, 89(19):2002-2009.
Tomadesso C, de La Sayette V, de Flores R, et al. Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloidnegative amnestic mild cognitive impairment patients[J]. Alzheimers Dement(Amst), 2018, 10:269-277.
Matias-Guiu JA, Cabrera-Martín MN, Curiel RE, et al. Comparison between FCSRT and LASSI-L to detect early stage Alzheimer's disease[J]. J Alzheimers Dis, 2018, 61(1):103-111.
Sanabria A, Alegret M, Rodriguez-Gomez O, et al. The Spanish version of face-name associative memory exam(S-FNAME)performance is related to amyloid burden in subjective cognitive decline[J]. Sci Rep, 2018, 8(1):3828.
Shokouhi S, Conley AC, Baker SL, et al. The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults[J]. Neurobiol Aging, 2019, 81:22-29.
Chapman S, Sunderaraman P, Joyce JL, et al. Optimizing subjective cognitive decline to detect early cognitive dysfunction[J]. J Alzheimers Dis, 2021, 80(3):1185-1196.
Perrotin A, Mormino EC, Madison CM, et al. Subjective cognition and amyloid deposition imaging: a Pittsburgh compound B positron emission tomography study in normal elderly individuals[J]. Arch Neurol, 2012, 69(2):223-229.
Tsoy E, Strom A, Iaccarino L, et al. Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET[J]. Alzheimers Res Ther, 2021, 13(1):36.
Sánchez-Benavides G, Salvadó G, Arenaza-Urquijo EM, et al. Quantitative informant-and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOEε4[J]. Alzheimers Dement(Amst), 2020, 12(1):e12127.
Pérez-Cordón A, Monté-Rubio G, Sanabria A, et al. Subtle executive deficits are associated with higher brain amyloid burden and lower cortical volume in subjective cognitive decline: the FACEHBI cohort[J]. Sci Rep, 2020, 10(1):17721.
Yoon HJ, Kim SG, Kim SH, et al. Distinct neural correlates of executive function by amyloid positivity and associations with clinical progression in mild cognitive impairment[J]. Yonsei Med J, 2019, 60(10):935-943.
Landau SM, Horng A, Jagust WJ, et al. Memory decline accompanies subthreshold amyloid accumulation[J]. Neurology, 2018, 90(17):e1452-e1460.
Aschenbrenner AJ, Balota DA, Tse CS, et al. Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults[J]. Neuropsychology, 2015, 29(3):368-381.
Jung Y, Whitwell JL, Duffy JR, et al. Amyloid burden correlates with cognitive decline in Alzheimer's disease presenting with aphasia[J]. Eur J Neurol, 2014, 21(7):1040-1043.
Eyigoz E, Mathur S, Santamaria M, et al. Linguistic markers predict onset of Alzheimer's disease[J]. EClinicalMedicine, 2020, 28:100583.
Whitwell JL, Weigand SD, Duffy JR, et al. Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech[J]. Neuroimage Clin, 2016, 11:90-98.
Adamczuk K, De Weer AS, Nelissen N, et al. Functional changes in the language network in response to increased amyloid β deposition in cognitively intact older adults[J]. Cereb Cortex, 2017, 27(7):3879.
Park SS, Park HS, Kim CJ, et al. Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer's disease[J]. Alzheimers Res Ther, 2020, 12(1):62.
Hou K, Zhao J, Wang H, et al. Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer's disease[J]. Nat Commun, 2020, 11(1):4790.
Zhang S, Zhao JH, Zhang YH, et al. Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease[J]. Alzheimers Res Ther, 2019, 11(1):54.
Jagust W. Is amyloid-β harmful to the brain?Insights from human imaging studies[J]. Brain, 2016, 139(Pt 1):23-30.
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