默认网络子系统介导AD谱系患者情节记忆功能障碍的神经影像学研究进展

姚维娜; 柏峰

doi:10.13406/j.cnki.cyxb.002920

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默认网络子系统介导AD谱系患者情节记忆功能障碍的神经影像学研究进展

认知障碍与中枢生物标志物关系研究 | 更新时间：2022-06-24

- 默认网络子系统介导AD谱系患者情节记忆功能障碍的神经影像学研究进展
- Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients
- 重庆医科大学学报 2021年46卷第11期页码：1395-1398
- 作者机构：
  
  1.南京中医药大学中西医结合鼓楼临床医学院，南京　210008
  2.南京大学医学院附属鼓楼医院神经内科，南京　210008
- 作者简介：
  
  [ "姚维娜，Email：yaoweina511@126.com，研究方向：神经认知与功能影像。" ]
  柏峰，教授、博导。国家优青、教育部新世纪优秀人才、中国杰出青年神经内科医师、江苏省医学重点人才、江苏省“六大人才高峰”、江苏省“333工程”人才、江苏省优青、南京市有突出贡献中青年专家、南京市中青年拔尖人才。中国卒中学会脑小血管病分会副主任委员、中国医促会神经病学分会青委会副主任委员、阿尔茨海默病防治协会神经认知专业委员会秘书长、江苏省卒中学会青委会主任委员、江苏省老年医学会神经病学分会副主任委员等学术兼职。发表SCI收录论文90篇，主持5项国家自然科学基金以及7项省部级科研项目，研究成果作为重要组成部分获得省部级科技奖一等奖4项。Email：baifeng515@126.com。
- 基金信息：
  
  国家自然科学基金面上资助项目(82071186)
- DOI：10.13406/j.cnki.cyxb.002920
  中图分类号： R741.02
- 纸质出版日期：2021-11-28，
  
  收稿日期：2021-08-01，
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姚维娜, 柏峰. 默认网络子系统介导AD谱系患者情节记忆功能障碍的神经影像学研究进展[J]. 重庆医科大学学报, 2021,46(11):1395-1398.

Weina Yao, Feng Bai. Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1395-1398.
姚维娜, 柏峰. 默认网络子系统介导AD谱系患者情节记忆功能障碍的神经影像学研究进展[J]. 重庆医科大学学报, 2021,46(11):1395-1398. DOI： 10.13406/j.cnki.cyxb.002920.

Weina Yao, Feng Bai. Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1395-1398. DOI： 10.13406/j.cnki.cyxb.002920.

摘要

阿尔茨海默病（Alzheimer's disease，AD）及其风险人群轻度认知障碍（mild cognitive impairment，MCI）是最常见的认知功能障碍，其核心损害表现为情节记忆功能障碍。默认网络（default network，DMN）由核心子系统（Core）、背内侧前额叶子系统（dorsal medial prefrontal cortex，DMPFC）和内侧颞叶子系统（medial temporal lobe，MTL）组成，3个子系统相互协作共同维持情节记忆功能的稳态。然而，AD谱系患者中上述子系统的相互作用模式尚不明确。本文将系统回顾该领域的研究进展，揭示AD谱系患者特有的损害特征，这将为AD谱系疾病早期筛查、进展监控、疗效评估以及相关认知障碍疾病的鉴别诊断提供重要的思路。

Abstract

Alzheimer's disease (AD) and its risk population of mild cognitive impairment (MCI) are the most common cognitive impairments

whose core impairment is episodic memory dysfunction. The default network (DMN) is composed of the core subsystem (Core)

the dorsal medial prefrontal cortex (DMPFC) subsystem and the medial temporal lobe (MTL) subsystem. The three subsystems cooperate with each other to maintain the steady state of episodic memory function. However

the patterns of interaction of these subsystems in AD spectrum patients are not clear yet. In this study

we will systematically review the advances of neuroimaging studies in this field

and the specific impairment characteristics of AD spectrum patients

which will provide important ideas for early screening

progression monitoring

efficacy evaluation and differential diagnosis of AD spectrum diseases.

关键词

情节记忆功能障碍默认网络子系统稳态神经影像

Keywords

episodic memory dysfunctiondefault networksubsystemsteady stateneuroimaging

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