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脑小血管病患者认知、睡眠和血浆标志物的研究进展
Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease
- 重庆医科大学学报 2021年46卷第11期 页码：1342-1347
- 作者机构：
海军军医大学第二附属医院神经内科，上海 200003
- 作者简介：
[ "陈晓晗，Email：1064418472@qq.com，研究方向：脑血管病、认知、睡眠。" ]
尹又，主任医师，硕导，上海市医学会神经病学分会青年副主任委员、上海市医学会痴呆与认知功能障碍学组副组长、上海市医师协会神经病学分会委员；申请国际、国防、国家发明、实用新型等专利24项；发表国内外学术论文70余篇，其中SCI论文第一/通信作者13篇；发表教学论文9篇。获中国睡眠医学第九届学术会议优秀论文二等奖、获《临床医学研究与实践杂志》2017/2019医学科技成果一等奖。Email：yinyou19@163.com。
- 基金信息：上海市科委资助项目(19441907500);上海长征医院资助项目(2020YLCYJ-Y02;2020CZWJFW12)
DOI：10.13406/j.cnki.cyxb.002915
中图分类号： R320.54纸质出版日期：2021-11-28，
收稿日期：2021-07-03，
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陈晓晗, 龚宝峰, 褚坚坚, 等. 脑小血管病患者认知、睡眠和血浆标志物的研究进展[J]. 重庆医科大学学报, 2021,46(11):1342-1347.
Xiaohan Chen, Baofeng Gong, Jianjian Chu, et al. Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1342-1347.
陈晓晗, 龚宝峰, 褚坚坚, 等. 脑小血管病患者认知、睡眠和血浆标志物的研究进展[J]. 重庆医科大学学报, 2021,46(11):1342-1347. DOI： 10.13406/j.cnki.cyxb.002915.
Xiaohan Chen, Baofeng Gong, Jianjian Chu, et al. Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1342-1347. DOI： 10.13406/j.cnki.cyxb.002915.
摘要
近年来随着神经影像技术的提高与普及，越来越多的脑小血管病被正确识别，脑小血管病在老年人群中已经成为一类常见病。脑小血管病能够引起一系列威胁患者健康的问题，尤其是认知功能损害，但由于疾病早期症状不突出，影像学检查滞后等原因，目前临床仍然缺乏有效的手段尽早识别此类疾病。本文阐述了脑小血管病的影像分型以及其特征性认知功能改变，探讨睡眠和血浆生物标志物与脑小血管病之间的关系，为临床早期鉴别诊断和个体化治疗提供有力依据。
Abstract
In recent years
with the improvement and popularization of neuroimaging technology
more and more cases of cerebral small vessel disease (CSVD) have been correctly identified
and it has become a common disease among the elderly. CSVD can cause a series of problems threatening patients'health
especially cognitive impairment. However
due to the lack of prominent early symptoms and lagging imaging examination
there is still a lack of effective means to identify such diseases as soon as possible. This paper expounds the imaging classification of CSVD and its characteristic cognitive function changes
and discusses its relationship between sleep and plasma biomarkers
so as to provide a strong basis for early clinical differential diagnosis and individualized treatment.
关键词
脑小血管病影像分型认知功能睡眠血浆生物标志物
Keywords
cerebral small vessel diseaseimaging classificationcognitive functionsleepplasma biomarkers
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