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阿尔茨海默病患者的视觉环路损害特征及其临床应用的研究进展
Research progress of the characteristics of abnormal visual pathway and its clinical application in patients with Alzheimer's disease
- 重庆医科大学学报 2021年46卷第11期 页码：1388-1390
- 作者机构：
1.江苏大学鼓楼临床医学院神经内科，南京 210008
2.南京大学医学院附属鼓楼医院神经内科，南京 210008
- 作者简介：
[ "王莲莲，Email：wanglianlian610@163.com，研究方向：神经认知与神经影像学。" ]
柏峰，教授、博导。国家优青、教育部新世纪优秀人才、中国杰出青年神经内科医师、江苏省医学重点人才、江苏省“六大人才高峰”、江苏省“333工程”人才、江苏省优青、南京市有突出贡献中青年专家、南京市中青年拔尖人才。中国卒中学会脑小血管病分会副主任委员、中国医促会神经病学分会青委会副主任委员、阿尔茨海默病防治协会神经认知专业委员会秘书长、江苏省卒中学会青委会主任委员、江苏省老年医学会神经病学分会副主任委员等学术兼职。发表SCI收录论文90篇，主持5项国家自然科学基金以及7项省部级科研项目，研究成果作为重要组成部分获得省部级科技奖一等奖4项。Email：baifeng515@126.com。
- 基金信息：国家自然科学基金面上资助项目(82071186)
DOI：10.13406/j.cnki.cyxb.002905
中图分类号： R741纸质出版日期：2021-11-28，
收稿日期：2021-07-25，
扫 描 看 全 文
王莲莲, 柏峰. 阿尔茨海默病患者的视觉环路损害特征及其临床应用的研究进展[J]. 重庆医科大学学报, 2021,46(11):1388-1390.
Lianlian Wang, Feng Bai. Research progress of the characteristics of abnormal visual pathway and its clinical application in patients with Alzheimer's disease[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1388-1390.
王莲莲, 柏峰. 阿尔茨海默病患者的视觉环路损害特征及其临床应用的研究进展[J]. 重庆医科大学学报, 2021,46(11):1388-1390. DOI： 10.13406/j.cnki.cyxb.002905.
Lianlian Wang, Feng Bai. Research progress of the characteristics of abnormal visual pathway and its clinical application in patients with Alzheimer's disease[J]. Journal of Shanxi Agricultural Sciences, 2021,46(11):1388-1390. DOI： 10.13406/j.cnki.cyxb.002905.
摘要
阿尔茨海默病（Alzheimer's disease，AD）是老年人中最常见的痴呆类型，表现为进展性、不可逆转的多维度认知功能障碍。视觉功能障碍是AD及其高风险人群轻度认知功能障碍（mild cognitive impairment，MCI）的认知损害特征之一，视觉环路功能障碍是其视觉症状的主要机制。利用神经影像学可以揭示AD谱系患者视觉环路的损害模式，有助于早期识别并干预AD的进展。本文将对AD谱系患者的视觉环路损害特征及其临床应用的研究进展进行综述。
Abstract
Alzheimer's disease (AD) is the most common form of dementia in the elderly who is characterized by progressive and irreversible loss of multidimensional cognitive function. Visual impairment is one of the features in AD and its high-risk population mild cognitive impairment (MCI) patients
and visual pathway dysfunction is associated with the underlying mechanism. Neuroimaging can reveal subtle changes in visual pathway in AD spectrum patients
which could help to early recognize and intervene in the progress of AD. In this article
we will review the progress of characteristics of abnormal visual pathway and its clinical application in AD spectrum patients.
关键词
阿尔茨海默病视觉环路神经影像学
Keywords
Alzheimer's diseasevisual pathwayneuroimaging
references
Villain N, Dubois B. Alzheimer's disease including focal presentations[J]. Semin Neurol, 2019, 39(2):213-226.
Lane CA, Hardy J, Schott JM. Alzheimer's disease[J]. Eur J Neurol, 2018, 25(1):59-70.
Tiwari S, Atluri V, Kaushik A, et al. Alzheimer's disease: pathogenesis, diagnostics, and therapeutics[J]. Int J Nanomedicine, 2019, 14:5541-5554.
Lenoir H, Siéroff É. Visual perceptual disorders in Alzheimer's disease[J]. Geriatr Psychol Neuropsychiatr Vieil, 2019, 17(3):307-316.
Oishi Y, Imamura T, Shimomura T, et al. Visual texture Agnosia in dementia with Lewy bodies and Alzheimer's disease[J]. Cortex, 2018, 103:277-290.
Salobrar-García E, de Hoz R, Ramírez AI, et al. Changes in visual function and retinal structure in the progression of Alzheimer's disease[J]. PLoS One, 2019, 14(8):e0220535.
Kim HJ, Cheong EN, Jo S, et al. Early impairment in the ventral visual pathway can predict conversion to dementia in patients with amyloid-negative amnestic mild cognitive impairment[J]. Alzheimer Dis Assoc Disord, 2021, 35(4):298-305.
Sasaki H, Fujimoto Y, Ima H, et al. Visualization of hypermetabolism in the ventral visual pathway by FDG-PET in the Charles Bonnet syndrome[J]. Clin Neurol Neurosurg, 2021, 208:106832.
McLachlan E, Bousfield J, Howard R, et al. Reduced parahippocampal volume and psychosis symptoms in Alzheimer's disease[J]. Int J Geriatr Psychiatry, 2018, 33(2):389-395.
Jacobs HI, Gronenschild EH, Evers EA, et al. Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study[J]. Cortex, 2015, 64:394-406.
Gallivan JP, Goodale MA. The dorsal“action”pathway[J]. Handb Clin Neurol, 2018, 151:449-466.
Gilaie-Dotan S. Visual motion serves but is not under the purview of the dorsal pathway[J]. Neuropsychologia, 2016, 89:378-392.
Yamasaki T, Horie S, Muranaka H, et al. Relevance of in vivo neurophysiological biomarkers for mild cognitive impairment and Alzheimer's disease[J]. J Alzheimers Dis, 2012, 31(S 3):137-154.
Freud E, Plaut DC, Behrmann M. ‘What'is happening in the dorsal visual pathway[J]. Trends Cogn Sci, 2016, 20(10):773-784.
Verhoef BE, Vogels R, Janssen P. Binocular depth processing in the ventral visual pathway[J]. Philos Trans R Soc Lond B Biol Sci, 2016, 371(1697):20150259.
Bracci S, Ritchie JB, de Beeck HO. On the partnership between neural representations of object categories and visual features in the ventral visual pathway[J]. Neuropsychologia, 2017, 105:153-164.
Vaziri-Pashkam M, Xu YD. Goal-directed visual processing differentially impacts human ventral and dorsal visual representations[J]. J Neurosci, 2017, 37(36):8767-8782.
Babo-Rebelo M, Puce A, Bullock D, et al. Visual information routes in the posterior dorsal and ventral face network studied with intracranial neurophysiology and white matter tract endpoints[J]. Cereb Cortex, 2021, 1991:bhab212.
Han SD, Bangen KJ, Bondi MW. Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer's disease: review and recommendations[J]. Dement Geriatr Cogn Disord, 2009, 27(1):1-10.
Mayo CD, Garcia-Barrera MA, Mazerolle EL, et al. Relationship between DTI metrics and cognitive function in Alzheimer's disease[J]. Front Aging Neurosci, 2019, 10:436.
Finsterwalder S, Vlegels N, Gesierich B, et al. Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients[J]. Alzheimers Dement, 2020, 16(11):1504-1514.
Chandra A, Dervenoulas G, Politis M, et al. Magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment[J]. J Neurol, 2019, 266(6):1293-1302.
Arkin SC, Ruiz-Betancourt D, Jamerson EC, et al. Deficits and compensation: attentional control cortical networks in schizophrenia[J]. Neuroimage Clin, 2020, 27:102348.
Migliaccio R, Gallea C, Kas A, et al. Functional connectivity of ventral and dorsal visual streams in posterior cortical atrophy[J]. J Alzheimers Dis, 2016, 51(4):1119-1130.
Bullock D, Takemura H, Caiafa CF, et al. Associative white matter connecting the dorsal and ventral posterior human cortex[J]. Brain Struct Funct, 2019, 224(8):2631-2660.
Salat DH, Tuch DS, van der Kouwe AJ, et al. White matter pathology isolates the hippocampal formation in Alzheimer's disease[J]. Neurobiol Aging, 2010, 31(2):244-256.
Villain N, Chételat G, Desgranges B, et al. Neuroimaging in Alzheimer's disease: a synthesis and a contribution to the understanding of physiopathological mechanisms[J]. Biol Aujourdhui, 2010, 204(2):145-158.
Wermke M, Sorg C, Wohlschläger AM, et al. A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease[J]. Eur J Nucl Med Mol Imaging, 2008, 35(1):12-24.
Zhao AN, Fang F, Li BY, et al. Visual abnormalities associate with Hippocampus in mild cognitive impairment and early Alzheimer's disease[J]. Front Aging Neurosci, 2020, 12:597491.
Huang J, Beach P, Bozoki A, et al. Alzheimer's disease progressively alters the face-evoked visual-processing network[J]. J Alzheimers Dis, 2020, 77(3):1025-1042.
Brown HD, Woodall RL, Kitching RE, et al. Using magnetic resonance imaging to assess visual deficits: a review[J]. Ophthalmic Physiol Opt, 2016, 36(3):240-265.
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