Metabolic programming means that nutrition and other environmental factors can change the epigenetic characteristics of the organism during the embryonic period and key stages of the development and maturation of vital organs in humans and other mammals

thereby affecting the normal development and maturity of these organs. It makes corresponding changes in organ development

material metabolism

immune stress

etc.

which will eventually lead to permanent changes in function and metabolism

and increase the susceptibility of many chronic diseases in adulthood. Because the unfavorable outcome of abnormal metabolic programming exists between two generations

and may form a vicious circle between "parents-offspring-parents". It seriously threatens the health of several generations and has become a major issue in the world. Health and economic burden. Our research team has been committed to breaking this vicious circle for many years. This article reviews the research progress made by the research team and aims to provide a new basis for controlling the occurrence and development of metabolic diseases from the source.