Objective: To explore a reasonable treatment for patients with vaginal stump cancer after hysterectomy for cervical intraep ithelial neoplasia (CIN). Methods: A retrospective analysis was made on the clinical data of 24 patients who were diagnosed with vaginal stump cancer after hysterectomy for CIN from January 2011 to December 2019 in Chongqing University Cancer Hospital. The mean age was (55.83±7.64) years. The duration from the first operation to vaginal stump cancer was (54.83±36.23) months. And 83.33% (20/24) of the patients were high-risk HPV positive. Among them

2 patients were treated with surgery alone

7 patients with surgery combined radiation±chemotherapy

11 patients with radiation and chemotherapy

and 4 patients gave up treatment. Results: Twenty patients were followed up after treatment. One patient was lost. The mean follow-up time was (44.95±32.98) months

2 of 19 patients died

and the overall survival rate was 89.47%. Conclusion: Prevention is more important for patients with vaginal stump cancer after CIN

and treatment should follow the principle of individualization.