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淀粉样蛋白和tau蛋白PET显像在痴呆中的临床研究进展
Clinical research progress of amyloid and tau protein PET imaging in dementia
- 重庆医科大学学报 2021年46卷第7期 页码：813-817
- 作者机构：
复旦大学附属华山医院PET中心，上海 200235
- 作者简介：
[ "张慧玮，Email：zhanghuiwei@fudan.edu.cn，研究方向：神经退行性疾病。" ]
左传涛，博士、博导、主任医师，复旦大学附属华山医院PET中心副主任、中华医学会核医学分会青年委员会副主任委员。承担国家自然科学基金青年基金资助项目1项、面上基金资助项目3项，NSFC-NIH中美合作项目1项，在Brain、Neuroimage、J Cereb Blood Flow Metab、Hum Brain Mapp、Clin Nucl Med、Frontiers等国际权威期刊发表论文30余篇。
- 基金信息：国家自然科学基金资助项目(81901367;81971641)
DOI：10.13406/j.cnki.cyxb.002800
中图分类号： R445.5纸质出版日期：2021-07-28，
收稿日期：2021-03-04，
扫 描 看 全 文
张慧玮, 左传涛. 淀粉样蛋白和tau蛋白PET显像在痴呆中的临床研究进展[J]. 重庆医科大学学报, 2021,46(7):813-817.
Huiwei Zhang, Chuantao Zuo. Clinical research progress of amyloid and tau protein PET imaging in dementia[J]. Journal of Shanxi Agricultural Sciences, 2021,46(7):813-817.
张慧玮, 左传涛. 淀粉样蛋白和tau蛋白PET显像在痴呆中的临床研究进展[J]. 重庆医科大学学报, 2021,46(7):813-817. DOI： 10.13406/j.cnki.cyxb.002800.
Huiwei Zhang, Chuantao Zuo. Clinical research progress of amyloid and tau protein PET imaging in dementia[J]. Journal of Shanxi Agricultural Sciences, 2021,46(7):813-817. DOI： 10.13406/j.cnki.cyxb.002800.
摘要
人口老龄化导致痴呆，特别是阿尔茨海默病（Alzheimer's disease，AD）的发病率、患病率呈明显上升态势。正电子发射断层显像（positron emission tomography，PET）是近年来蓬勃发展的分子影像学诊断技术之一。在痴呆领域中，以神经病理学为基础，放射性标记的淀粉样蛋白和tau蛋白正电子显像剂可以客观地检测脑内异常蛋白沉积分布情况，可广泛应用于AD的早期诊断与鉴别诊断、疾病进展与预后评估等方面。本文主要针对淀粉样蛋白和tau蛋白正电子显像剂的发展和临床研究现状进行综述。
Abstract
The aging of the population has led to a significant increase in the incidence and prevalence rate of dementia
especially Alzheimer's disease (AD). Positron emission tomography (PET) is one of the most advanced molecular imaging diagnostic techniques in recent years. In the field of dementia
based on neuropathology
radio-labeled molecular probes of amyloid and tau tracer can objectively detect the distribution of abnormal protein deposition in the brain
which can be widely used in the early diagnosis and differential diagnosis of AD
disease progression and prognosis assessment. This paper focuses on the development and clinical research status of molecular probes for amyloid and tau protein.
关键词
阿尔茨海默病诊断正电子显像剂
Keywords
Alzheimer's diseasediagnosispositron imaging agent
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