脑库神经系统变性疾病的病理诊断

竺可青; 毛晨晖; 杜鹃; 张蕾

doi:10.13406/j.cnki.cyxb.002798

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脑库神经系统变性疾病的病理诊断

神经肌肉病理和电生理诊断 | 更新时间：2022-06-24

- 脑库神经系统变性疾病的病理诊断
- Neurodegenerative diseases pathological diagnosis in brain bank
- 重庆医科大学学报 2021年46卷第7期页码：781-785
- 作者机构：
  
  1.浙江大学医学院国家健康与疾病人脑组织资源库，杭州　310058
  2.北京协和医院神经内科，北京　100730
  3.河北医科大学人体解剖学教研室、河北医科大学人脑组织库，石家庄　050017
- 作者简介：
  
  [ "竺可青，博士，浙江大学医学院神经病理学副教授，浙江大学医学院国家健康与疾病人脑组织资源库副主任。先后在美国加州大学旧金山分校神经内科系进行博士后训练，以及在荷兰神经科学研究所及脑库做访问学者。发表论文30余篇，主持和完成国家及省部级科研项目多项。研究方向：基于脑库的神经病理研究。Email：zhukeqing@zju.edu.cn。" ]
- 基金信息：
  
  国家自然科学基金面上资助项目(81971184)
- DOI：10.13406/j.cnki.cyxb.002798
  中图分类号： R741.04
- 纸质出版日期：2021-07-28，
  
  收稿日期：2021-01-27，
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竺可青, 毛晨晖, 杜鹃, 等. 脑库神经系统变性疾病的病理诊断[J]. 重庆医科大学学报, 2021,46(7):781-785.

Keqing Zhu, Chenhui Mao, Juan Du, et al. Neurodegenerative diseases pathological diagnosis in brain bank[J]. Journal of Shanxi Agricultural Sciences, 2021,46(7):781-785.
竺可青, 毛晨晖, 杜鹃, 等. 脑库神经系统变性疾病的病理诊断[J]. 重庆医科大学学报, 2021,46(7):781-785. DOI： 10.13406/j.cnki.cyxb.002798.

Keqing Zhu, Chenhui Mao, Juan Du, et al. Neurodegenerative diseases pathological diagnosis in brain bank[J]. Journal of Shanxi Agricultural Sciences, 2021,46(7):781-785. DOI： 10.13406/j.cnki.cyxb.002798.

摘要

随着脑计划在国内的开展，脑库工作将在其中起重要作用。神经系统变性疾病为脑库相关疾病的重要组成部分，对其进行严格的神经病理诊断具有重要意义。本文结合作者在脑库工作中的经验，对常见神经系统变性疾病的病理特点进行重点概述，对近年来在阿尔茨海默病、原发性衰老相关性tau病等疾病的病理诊断进展进行介绍，力图建立脑库神经系统变性疾病病理诊断的标准化程序。

Abstract

With the development of brain project in China

brain bank work will play an important role in the project. Neurodegenerative diseases contribute an important part in brain bank diseases

and it is of great significance to make a strict neuropathological diagnosis. In this article

combined with the author's working experience in brain bank

this paper focuses on summarizing the pathological characteristics of common neurodegenerative diseases

and introduces the pathological diagnosis progress of Alzheimer's disease

primary aging-related tauopathy and other diseases introduced in recent years

trying to establish a standardized procedure for pathological diagnosis of neurodegenerative diseases in brain bank.

关键词

脑库神经系统变性疾病阿尔茨海默病原发性衰老相关性tau病

Keywords

brain bankneurodegenerative diseasesAlzheimer's diseaseprimary aging-related tauopathy

references

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Crary JF, Trojanowski JQ, Schneider JA, et al. Primary age-related tauopathy(PART): a common pathology associated with human aging[J]. Acta Neuropathol, 2014, 128(6):755-766.

Zhu K, Wang X, Sun B, et al. primary age-related tauopathy in human subcortical nuclei[J]. Front Neurosci, 2019, 13:529.

Zhang X, Sun B, Wang X, et al. phosphorylated TDP-43 staging of primary age-related tauopathy[J]. Neurosci Bull, 2019, 35(2):183-192.

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