Ischemic stroke is one of the leading causes of mortality and disability worldwide. Scientists have been trying to clarify the cellular and molecular pathophysiological processes. Long non-coding RNAs (lncRNAs) play an important role in a lot of diseases. Recent studies have found that there were a bulk of differentially expressed lncRNAs in both ischemic stroke patients and animal models. They participated in regulating cell apoptosis

angiogenesis

inflammation

and cell death. Those investigations may help to elucidate the mechanisms and functions of lncRNAs in ischemic stroke

which may provide new strategies for seeking new biomarkers and therapeutic targets of ischemic stroke.