In the pathogenesis of ischemic stroke

due to the breakdown of blood-brain barrier structures such as endothelial cells

reperfusion injury

and coagulation dysfunction after thrombolytic therapy

etc.

the restored blood flow enters the brain tissue from the damaged blood vessels

which is called hemorrhagic transformation (HT). Severe HT is one of the causes of death in patients. Researches find that HT may be related to many factors

such as venerable age

diabetes

and the severity of the patient's condition. It will be helpful for the prevention and treatment of clinical HT whether the probability of HT can be determined quantitatively by biological markers and reduced by management. Therefore

this paper reviews the advances in this area.