Objective: To study the clinical significance of red blood cell distributioin width to platelet ratio (RPR) in the diagnosis

treatment and staging of multiple myeloma (MM)

and to comprehensively analyze the applicative value of RPR combined with other relevant indicators. Methods: A total of 51 eligible MM patients who were diagnosed in the North China University of Science and Technology Affiliated Hospital from October 2013 to October 2018 were collected as the case group

while 51 healthy subjects who underwent examination in the same period of time in the same hospital were selected as the control group for retrospective analysis. RPR was calculated based on blood routine results

and the differences in RPR

inflammatory indexes including

red blood cell distribution width (RDW)

C-reactive protein (CRP)

albumin/globumin (A/G)

platelet (PLT)

mean platelet volume (MPV)

D-dimmer (D-D)

classic staging index beta 2-macroglobulin (β2-MG) and prognostic evaluation indicator lactate dehydrogenase (LDH) between two groups were compared. According to ISS staging criteria

MM patients were divided into three groups: phaseⅠ

Ⅱ

andⅢ. The differences between RPR and related indexes in different stages were analyzed. The correlation of RPR and inflammatory indicators A/G

coagulation indicators MPV and D-D

and classical staging indicator β2-MG were respectively studied in the case group. Results: There were statistically significant differences in RPR

inflammatory indexes

coagulation indexes

the classic staging index and prognosis evaluation indicator between the case group and the control group (P=0.000

0.000

0.000

0.000

0.004

0.006

0.000

0.000

0.000). For the comparison of indicators among three groups

RPR and other indicators had statistical significance (P=0.000). By pairwise comparison

levels of RPR

RDW

CRP

LDH

D-D and β2-MG were increased with the development of the disease

while levels of PLT

A/G and MPV were decreased with the development of the disease. For the correlation analysis between RPR and some indicators in the case group

RPR was positively correlated with D-D and β2-MG (r=0.590

0.803; P=0.000

0.000)

and was negatively correlated with A/G and MPV (r=-0.583

-0.500; P=0.000

0.000). Conclusion: RPR can reflect the inflammation and bleeding state

and has certain clinical auxiliary significance for the diagnosis

treatment and staging of MM.