<sup>18</sup>F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值

李敏; 李绪清; 颜士杰; 仲飞; 吴大保

doi:10.13406/j.cnki.cyxb.001417

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¹⁸F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值

临床研究 | 更新时间：2024-01-17

- ¹⁸F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值
- Value of ¹⁸F-fluorodeoxyglucose PET/CT combined with serum carbohydrate antigen 125 in detecting the recurrence and metastasis of postoperative ovarian cancer
- 重庆医科大学学报 2017年42卷第12期页码：1635-1638
- 作者机构：
  
  1. 安徽医科大学第一附属医院妇产科
  2. 安徽医科大学第一附属医院肿瘤内科
  3. 安徽医科大学附属省立医院妇产科
- 作者简介：
- 基金信息：
  
  中国博士后科学基金资助项目(编号:2016M590560)
- DOI：10.13406/j.cnki.cyxb.001417
  中图分类号： R730.44;R737.31
- 纸质出版日期：2017，
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李敏, 李绪清, 颜士杰, 等. ¹⁸F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值[J]. 重庆医科大学学报, 2017,42(12):1635-1638.

Li Min, Li Xuqing, Yan Shijie, et al. Value of ¹⁸F-fluorodeoxyglucose PET/CT combined with serum carbohydrate antigen 125 in detecting the recurrence and metastasis of postoperative ovarian cancer[J]. Journal of Chongqing Medical University, 2017,42(12):1635-1638.
李敏, 李绪清, 颜士杰, 等. ¹⁸F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值[J]. 重庆医科大学学报, 2017,42(12):1635-1638. DOI： 10.13406/j.cnki.cyxb.001417.

Li Min, Li Xuqing, Yan Shijie, et al. Value of ¹⁸F-fluorodeoxyglucose PET/CT combined with serum carbohydrate antigen 125 in detecting the recurrence and metastasis of postoperative ovarian cancer[J]. Journal of Chongqing Medical University, 2017,42(12):1635-1638. DOI： 10.13406/j.cnki.cyxb.001417.

摘要

目的:研究

F-脱氧葡萄糖(

F-fluorodeoxyglucose

F-FDG)PET/CT联合糖类抗原125（carbohydrate antigen 125

CA125）在诊断卵巢上皮癌复发转移中的价值。方法:回顾性分析61例卵巢上皮癌患者首次减瘤术后PET/CT和血清CA125的检测结果

根据患者的随访资料及二次手术病理结果

分析其联合检查在卵巢癌复发转移中的诊断价值。结果:卵巢上皮癌复发转移时

F-FDG PET/CT扫描呈现局部高代谢表现。独立

F-FDG PET/CT显像诊断卵巢癌复发转移的灵敏度、准确率、特异度、阴性预测值及阳性预测值分别为96.08%、90.16%、60.00%、54.55%、98.00%。单独血清CA125诊断卵巢癌首次减瘤术后复发转移的灵敏度、准确率、特异度、阴性预测值及阳性预测值分别为76.47%、75.41%、70.00%、63.64%、78.00%。血清CA125组诊断卵巢癌术后复发转移的灵敏度、准确率、阳性预测值方面均相应地低于PET/CT组

两者比较均有统计学差异

其相应的P值分别为0.004、0.031、0.002。

F-FDG PET/CT联合血清CA125水平诊断卵巢上皮癌复发转移的灵敏度、准确率、特异度、阴性预测值、阳性预测值分别为98.04%、91.80%、60%、54.55%、100.00%。PET/CT联合CA125组在诊断卵巢癌术后复发转移的灵敏度、准确率、阳性预测值方面均高于CA125组

两者比较均有统计学差异

其相应的P值分别为0.001、0.015、0.001。血清CA125水平与PET/CT中卵巢癌复发转移病灶的最大标准摄取值（maximum standardized uptake value

SUVmax）呈正相关（r=0.672

P=0.029）。结论:

F-FDG PET/CT检查联合CA125检测在诊断卵巢上皮癌的复发转移中具有较高的灵敏度和准确率

可早期诊断确定卵巢癌术后复发

为进一步治疗决策提供依据。

Abstract

Objective:To analyze the value of combination of

F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen 125（CA125）in diagnosing the recurrence and metastasis of postoperative ovarian cancer.Methods:The results of PET/CT and serum CA125 in 61 cases of postoperative ovarian cancer were analyzed retrospectively.Their values in detecting the recurrence and metastasis of postoperative ovarian cancer were evaluated according to the secondly surgical pathology and clinical follow-up.Results:The local sites of recurrence and metastasis presented high-uptake of

F-fluorodeoxyglcose in PET/CT imaging.The sensitivity

accuracy

specificity

negative predictive value and positive predictive value of single

F-FDG PET/CT were 96.08%

90.16%

60.00%

54.55%and 98.00%

respectively.The sensitivity

accuracy

specificity

negative and positive predictive values of single serum CA125 were 76.47%

75.41%

70.00%

63.64%

78.00%

respectively.The sensitivity

accuracy and positive predictive value of serum CA125 were lower than those of PET/CT in detecting the recurrence and metastasis of postoperative ovarian cancer.There was significant difference in two groups and the P values were 0.004

0.031

0.002

respectively.The sensitivity

accuracy

specificity

negative and positive predictive values of combination of

F-fluorodeoxyglucose PET/CT with serum CA125 were 98.04%

91.80%

60%

54.55%

100.00%

respectively.The sensitivity

accuracy and positive predictive value of combination of

F-fluorodeoxyglucose PET/CT with serum CA125 were higher than those of single serum CA125 in detecting the recurrence and metastasis of postoperative ovarian cancer.There was significant difference in two groups and the P values were 0.001

0.015

0.001

respectively.The serum carbohydrate antigen 125 levels were positively correlated to the maximum standardized uptake value（SUVmax）of the recurrent and metastatic lesions in PET/CT（r=0.672

P=0.029）.Conclusion:The combinative detection of

F-fluorodeoxyglucose PET/CT and serum CA125 has high sensitivity and accuracy in diagnosis of recurrence and metastasis of ovarian cancer

which is a valuable and suitable strategy in the follow-up of postoperative ovarian cancer.

关键词

PET卵巢癌复发和转移糖类抗原125

Keywords

PETepithelial ovarian cancerrecurrence or metastasiscarbohydrate antigen125

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18F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值

Value of 18F-fluorodeoxyglucose PET/CT combined with serum carbohydrate antigen 125 in detecting the recurrence and metastasis of postoperative ovarian cancer

DOI：10.13406/j.cnki.cyxb.001417

摘要

Abstract

关键词

Keywords

references

¹⁸F-脱氧葡萄糖PET/CT联合CA125在诊断卵巢癌复发转移中的应用价值

Value of ¹⁸F-fluorodeoxyglucose PET/CT combined with serum carbohydrate antigen 125 in detecting the recurrence and metastasis of postoperative ovarian cancer