Objective:To systematically evaluate the effectiveness and safety of acupuncture and drugs for migraine prevention

and to facilitate the clinical application of acupuncture. Methods:Databases of Pubmed

Cochrane library

EMBASE

CBM

VIP

Wan Fang Data and CNKI were searched from database foundation to October 2015. The randomized controlled trials（RCTs）of acupuncture and drugs for migraine prophylaxis were screened and retrieved. The outcome data were grouped 3-4 months after randomization and 5-6months after randomization based on follow-up. And then

the included studies were assessed and data were extracted to do metaanalysis. Results:A total of 7 RCTs and 1 285 patients with migraine were included in this study. There were significant differences in response rate（RR=1.24

95%CI=1.04 to 1.47

P=0.020）

migraine days（SMD=-0.30

95%CI=-0.45 to-0.16

P=0.000）

intensity of headache（SMD=-0.32

95%CI=-0.52 to-0.11

P=0.000）during 3

4

months after randomization;and also in migraine days（MD=-0.66

95%CI=-1.18 to-0.13

P=0.010）

intensity of headache（SMD=-0.31

95%CI=-0.47 to-0.15

P=0.000）during 5-6 months after randomization; but there was no difference in response rate（RR=1.18

CI=0.97 to 1.43）

P=0.110)during 5-6 months after randomization. Compared to drug therapy

acupuncture group had more effectiveness

less migraine days

lighter headache intensity. It was fail to deal with heterogeneity（I2=77%）of adverse events;after descriptive analysis

there was less adverse events in research period.Conclusion:Acupuncture had better clinically effectiveness and more safety than drug therapy in migraine prophylaxis. More high quality researches should been carried on to enhance the reliability.