Objective:To explore tuberculosis incidence related to social economy vary across 38 counties of Chongqing area. Methods:Spearman rank correlation analysis and geographically weighted regression（GWR）were used to figure out the relationship between tuberculosis incidence and social economy with four-year tuberculosis and social economic data from 2011 to 2014. Results:Incidence of tuberculosis concentrated in the northeast and southeast of Chongqing region（Moran’s I were 0.52

0.49

0.56

0.39

P=0.000）. Incidence of tuberculosis was negatively related to per capita GDP by Spearman rank correlation analysis（r were-0.612

-0.611

-0.631

-0.582 respectively

P=0.000）. GWR coefficients varied from-4.44 to 3.20. Northeast and southeast areas exhibited high influence on tuberculosis incidence and per capita GDP. Negative correlation distributed in a large area of 92% of the districts/counties.Conclusion:The influence of social economy on tuberculosis incidence varies across regions. Measure related to different regions on tuberculosis prevention and control should be developed.