Objective:To analyze and compare the efficacy of different anticoagulation strategies in continuous renal replacement therapy（CRRT）for patients with wasp stings and its nursing care. Methods:The clinical data of 31 patients with wasp stings in our department were retrospectively. Anticoagulated modes of CRRT such as none-heparin

local anticoagulant heparin or low molecular heparin sodium were used during 93 therapies. The lifetime of filter

the degree of venous pot coagulation and active bleeding index in three groups of patients with CRRT treatment were observed. Suitable nursing care was given according to the different ways of anticoagulant. Results:The lifetime of filter with none-heparin anticoagulation was significant different from that in the other groups（P<0.05）. There were significant differences in venous blood coagulation severity among three groups of patients（P=0.000）. One patient can’t complete bleed return because of blood coagulation in vitro. There were significant differences in active bleeding among three groups of patients（P =0.017）. Conclusion:Patients with wasp stings should be given corresponding anticoagulated modes according to the state of illness in CRRT treatment and the patients’ individual condition. Effective condition monitoring and nursing care can reduce or avoid unexpected anticoagulant blood clotting and hemorrhagic complications

as well as get the maximum therapeutic effect.