Objective:To investigate the association of single nucleotide polymorphisms（SNP）of ADAMTS4 and ADAMTS5 gene with coronary artery disease（CAD）. Methods:A case-control association study of 307 unrelated CAD patients and 315 normal controlfrom a Chinese Han Population was performed. Genotype and allele were determined bypolymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）and polymerase chain reaction-single-strand conformation polymorphism（PCR-SSCP）for SNP rs4233367

rs2830585 and rs229072. Results :The genotype frequencies of SNP rs2830585 in CAD group and the control group respectively were CC（87.0% vs. 78.4% ）

CT（12.7% vs. 20.6% ）and TT（0.3% vs. 1.0% ）

with statistically significance between the two groups（χ

2

=8.291

P=0.016）. The genotype frequencies of T allele were 6.7% and 11.3% respectively

with statistically significance between the two groups（χ

2

=8.004

P=0.005）. Logistic regression analysis revealed that ADAMTS5 gene rs2830585 had a strong associ ation with CAD（OR=1.777

95% CI=1.071 to 2.949

P=0.026）. Thefrequencies of the genotype and alleles ofrs4233367 and rs229072 had no statistical significance between two groups（P

>

0.05）. Conclusion:SNP rs2830585 polymorphisms of the ADAMTS5 gene may be associated with CAD. The C allele of the SNP rs2830585 may be a genetic risk factor for CAD.