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1. 重庆医科大学附属第一医院呼吸与危重症医学科
2. 重庆市荣昌区人民医院呼吸内科
3. 第三军医大学附属大坪医院野战外科研究所呼吸内科
纸质出版日期:2017,
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王晓慧, 古正凤, 张露, 等. 重庆地区肺栓塞患者临床资料回顾性调查分析[J]. 重庆医科大学学报, 2017,42(10):1314-1319.
Wang Xiaohui, Gu Zhengfeng, Zhang Lu, et al. Retrospective analysis of clinical diagnosis and treatment of pulmonary embolism in nearly ten years of Chongqing city[J]. Journal of Chongqing Medical University, 2017,42(10):1314-1319.
王晓慧, 古正凤, 张露, 等. 重庆地区肺栓塞患者临床资料回顾性调查分析[J]. 重庆医科大学学报, 2017,42(10):1314-1319. DOI: 10.13406/j.cnki.cyxb.001382.
Wang Xiaohui, Gu Zhengfeng, Zhang Lu, et al. Retrospective analysis of clinical diagnosis and treatment of pulmonary embolism in nearly ten years of Chongqing city[J]. Journal of Chongqing Medical University, 2017,42(10):1314-1319. DOI: 10.13406/j.cnki.cyxb.001382.
目的:了解重庆地区各级医院近10年肺栓塞诊治情况
为进一步提高及规范肺栓塞的预防、诊断和治疗提供依据。方法:收集重庆地区31家医院2003至2012年期间诊断为肺栓塞患者的临床资料
进行回顾性调查研究分析。结果:(1)31家医院共纳入336例患者
其中确诊195例
临床诊断141例
死亡105例。(2)主要合并基础疾病为高血压、创伤及手术、制动、肺癌、冠心病、肺部感染等。(3)主要临床表现为呼吸困难、咳嗽、胸痛、心悸、咳痰、晕厥。(4)非老年组确诊率比老年组更高
差异有统计学意义(67.14%vs.51.03%
P=0.003);非老年组死亡率低于老年组
差异有统计学意义(36.60%vs.24.29%
P=0.017)。(5)2008至2012年肺栓塞确诊率比2003至2007年肺栓塞更高
差异有统计学意义(62.23%vs.38.60%
P=0.000);2008至2012年肺栓塞患者死亡率低于2003至2007年肺栓塞患者死亡率
差异有统计学意义(49.12%vs.27.34%
P=0.000)。(6)三级医院确诊率比二级医院更高
差异有统计学意义(59.81%vs.31.58%
P=0.015);三级医院与二级医院患者死亡率比较差异无统计学意义(31.01%vs.36.84%
P=0.595)。(7)干预组与未干预组比较
未干预组死亡率更高
差异有统计学意义(14.53%vs.69.61%
P=0.000)。(8)多因素回归分析表明确诊率的独立因素为年龄(优势比:2.177
95%CI=1.356
3
.494)
时间(优势比:3.175
95%CI=1.720
5
.860)
医院等级(优势比:0.262
95%CI=0.094
0
.728)。死亡率的独立危险因素为时间(优势比:1.817
95%CI=0.895
3
.687)和有无干预措施(优势比:0.078
95%CI=0.044
0
.137)。结论:重庆地区大部分医院医务人员肺栓塞诊断意识逐年有所提高
但筛查肺栓塞高危患者及肺栓塞预防意识差。三级医院主要靠电子计算机断层扫描肺动脉造影(computed tomography pulmonary angiography
CTPA)确诊肺栓塞
各级医院诊断肺栓塞以临床综合诊断为主
确诊率低
但三级医院确诊率高于二级医院
非老年患者的确诊率高于老年患者。重庆地区肺栓塞的诊断及治疗肺栓塞欠规范
死亡率高。2003至2007年间死亡率高于2008至2012年
及时干预和治疗可降低死亡率。因此
重庆地区各医级院肺栓塞诊断及治疗水平有待大幅提高
以此降低肺栓塞的死亡率
改善预后。
Objective:To investigate the diagnosis and treatment of pulmonary embolism in hospitals of different medical levels in recent 10 years in order to provide evidences to improve the level of the pulmonary embolism prevention
diagnosis and treatment.Methods:The clinical data of 336 pulmonary embolism patients from 31 hospitals of different medical levels of Chongqing from January 2003 to December 2012 by convenience sampling method were investigated. The questionnaire included :the general situation
the underlying diseases and risk factors
clinical manifestations
examination findings
treatment and prognosis. Results:(1)A total of 336 patients(195 cases were confirmed
141 cases were diagnosed in clinical)of which 105 cases died.(2)The most common complicated diereses were hypertension
trauma and surgery
lung cancer
cardiac insufficiency
malignant tumor
diabetes
braking
lung infection.(3)The common symptoms were dyspnea
symptoms of deepvein
chest pain
palpitation
cough
sputum
and syncope.(4)The definite diagnose rate of un-elderly patients showed higher than that of elderly patients
the difference was significant(67.14% vs. 51.03%
P=0.003). The mortality of elderly patients was higher than that of non-elderly patients
and the difference was significant(36.60% vs. 24.29%
P=0.017).(5)The definite diagnose rate of patients who were diagnosed from 2008 to2012 was higher than patients who were diagnosed from 2003 to 2007
and the difference was significant(62.23% vs. 38.6%
P=0.000).The mortality of patients who were diagnosed from 2003 to 2007 was higher than that of patients who were diagnosed from 2008 to2012
and the difference was significant(49.12% vs. 27.34%
P=0.000).(6)The definite diagnose rate of tertiary hospitals was higher than that of second-class hospitals
and the difference was significant(59.81% vs. 31.58%
P=0.015);The difference of the mortality of between tertiary hospitals and second-class hospitals was not significant(31.01% vs. 36.84%
P=0.595).(7)The mortality of intervention group was higher than non-intervention group
the difference was significant(14.53% vs. 69.61%
P=0.000).(8)The multivariate regression analysis confirmed that the factors associated with the definite diagnose rate including the age(odds ratio:2.177
95%CI=1.356 to 3.494)
time(odds ratio:3.175
95%CI=1.720 to 5.860)
and the class of hospital(odds ratio:0.262
95%CI=0.094 to 0.728);the risk factors associated with the mortality including the time(odds ratio:1.817
95%CI=0.895 to 3.687)and untreated(odds ratio:0.078
95%CI=0.044 to 0.137). Conclusion:The consciousness of pulmonary embolism diagnosis is gradually improved for the most hospital medical staff from 2003 to 2012 in Chongqing
but the consciousness of prevention and screening high-risk patients with pulmonary embolism is poor. Tertiary hospitals mainly depend on computed tomography pulmonary angiography(CTPA)in the diagnosis of pulmonary embolism. Pulmonary embolism diagnosis mainly conduct in clinic in different medical levels hospitals
and the definite diagnose rate is low. While the definite diagnose rate of un-elderly patients is higher than that of elderly patients
and the the definite diagnose rate of tertiary hospitals is higher than that of second-class hospitals. The diagnosis and treatment of Pulmonary embolism is non-standard
and the mortality of pulmonary embolism is high. Treatment could decrease the mortality of the patient with pulmonary embolism. The ability of diagnosis and treatment of pulmonary embolism should be further improved.
肺栓塞调查治疗
pulmonary embolisminvestigationtreatment
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