Follicular helper T cells（Tfh）is recently defined as new subpopulations of CD4

+

lymphocytes

which is mainly engaged in lymphoid follicles. Tfh cell is the bridge of the interaction of T-B cells

which plays an important role in regulating B lymphocyte proliferation

differentiation of plasma cells and antibody class switching. The realization of the above functions are closely related to transcription factors（B-cell lymphoma 6）

cytokines（interleukin-21）

chemokine receptor（CXCR5）

costimulatory molecules（ICOS and CD40L）and co-inhibitory molecular（PD-1）. Studies of recent years discovered that the functional disturbances of Tfh plays an important role in autoimmunity diseases

infection and immune deficiency diseases. The biological characteristics of Tfh and the role of Tfh in the chronic liver disease were described in this review.