Objective:To identify the risk factors for bronchopulmonary dysplasia(BPD)in neonatal respiratory distress syndrome(NRDS). Methods:Data from 287 neonates with RDS who were hospitalized over 28 days were analyzed respectively. Results:Of the287 neonates

131 developed BPD. In univariate analysis

gestational age

birth weight

hospitalization duration

maternal age

cesarean section

the times of pulmonary surfactant(≥2 times)

the dose of pulmonary surfactant

the positive rate of sputum cultures

repeated mechanical ventilation

the mode of mechanical ventilation

the inhaled oxygen volume concentration

the duration of mechanical ventilation

the duration of oxygen

ventilator-associated pneumonia

pulmonary hypertension

patent ductus arteriosus(PDA)

the survival rate and the mortality

gran negative bacillus were all associated with an increase in the incidence of BPD(P<0.05). No significant differences was found in the first minute of Apgar score

the hospitalization time

the fetal distress

gestational complications

the rate of pulmonary surfactant

the time of pulmonary surfactant

the first blood gas analysis scores after birth

combined with neonatal necrotizing enterocolitis(NEC)

air leak

septicemia

retinopathy of prematurity(ROP)

intracranial hemorrhage

pneumorrhagia between the two groups(P>0.05). Multivariate logistic regression model showed that the high birth weight

cesarean section were protecting factors and the the positive rate of sputum cultures

repeated mechanical ventilation

the duration of oxygen and pulmonary hypertension were risk factors for BPD. Conclusion:Shortening the duration of oxygen and preventing the pulmonary hypertension are key methods to reduce BPD in neonates with RDS.