Metabolic inflammation mainly refers to a chronic low abundance of inflammatory response from macrophages

adipocytes

liver and other cells triggered by excess of nutrients. CD36（cluster of differentiation 36

FAT/CD36）

also known as a fatty acid transporter

is considered to be the hub for natural immunity and lipid metabolism. Fatty acids can induce CD36 expression in hepatocytes which can bind to the Toll-like receptors（TLR）4/6 and form heterodimers

leading to occurrence of inflammatory responses. Under the metabolic inflammation

liver uptakes and synthesizes more lipids

leading to nonalcoholic fatty liver disease（NAFLD）development.CD36 may be a potential target for the treatment of NAFLD.