Objective:To explore the thyroid function of patients with bipolar disorder mania/hypomania episode

depressive episode and mixed episode. Methods :Chemiluminescence immunoassay was used to test the serum thyroid stimulating hormone（TSH）

free triiodothyronine（FT3）

serum free thyroxine（FT4）

triiodothyronine（T3） and thyroxine（T4） level in 62 bipolar mania/hypomania episode patients

71 depressive episode patients

26 mixed episode patients and 203 normal controls. Experimental group and normal controls group were collected from the University-Town hospital of Chongqing Medical University. Results:Compared with that in the control group

TSH level was significantly lower[1.650（0.803

2.400）vs. 2.100（1.610

3.030）

P<0.01] and FT4 level was significantly higher[18.420（15.530

20.060）vs. 16.600（14.890

17.640）

P<0.01] in the bipolar mania/hypomania patients. T3 and T4 levels were significantly lower[1.580（1.180

1.890）vs. 1.770（1.610

1.990）

84.170（62.540

97.940）vs. 95.54（86.020

109.500）

P<0.01] in the depression episode patients

T3 level was significantly lower [1.440（1.273

1.783） vs. 1.770（1.610

1.990）

P <0.01] in the mixed episode patients than that in the control group. The T4

FT4 levels were significantly higher[96.39（76.768

123.040）vs. 84.170（62.540

97.940）

18.420（15.530

20.060）vs. 16.520（13.670

19.080）

P<0.05] in mania/hypomania episode patients than in depression episode patients. TSH levels in serum of bipolar patients with a family history was higher（1.786±1.3601 vs. 2.229±1.7511

P<0.05）than that of patients without a family history;T3 and T4 level were lower in women with bipolar disorder than in normal patients（1.362±0.674 vs. 1.769±0.290

78.407±39.180 vs. 96.396±22.635

P=0.000）. Conclusion:Thyroid function is abnormal when bipolar depressive episode

manic

mixed attack happens

but the abnormity of each are not identical.