Objective:To study the effect of different dosages of estradiol valerate（EV）on ovarian function and estrogen receptor（ESR1）expression after hysteroscopic adhesiolysis in patients with intrauterine adhesions（IUA）. Methods:Fifty-six patients suffered from IUA were recruited in our center of hysteroscopy

and treated by EV 4 mg（23 cases）

EV 6 mg（17 cases）

EV 9 mg（16 cases）and progesterone sequentially for three cycles therapy after hysteroscopic adhesiolysis. The patients were followed up the ovulation by detected progesterone hormone during and after treatment. Then

the patients’ endometrial tissues in EV 4 mg and EV 9 mg groups were investigated for ESR1 expressions by Western blot and q PCR before and after treatment. Results:In 56 patients

the rates of ovulation inhibition rate was 8.69% in EV 4 mg

58.82% in EV 6 mg

93.75% in EV 9 mg during treatment respectively（P<0.05）;the ovulation inhibition rate was 4.34% in EV 4 mg

17.64% in EV 6 mg

56.25% in EV 9 mg in the following month after treatment respectively（P<0.05）. ESR1 expression was decreased significantly only in all groups after treatment with hierarchical grouping. ESR1 expression in falling range was significant in serious IUA group with EV 9 mg compared with that of EV 4 mg（P<0.05）. Conclusion:The larger dosage of estrogen used

the more obviously ovulation inhibited. There was no significant advantage to decrease ESR1 expression with large dosage of estrogen.