宫腔粘连和子宫纵隔的宫腔镜手术预后与TGF-β1的关系

赵刚; 谢秀英; 薛翔

doi:10.13406/j.cnki.cyxb.001228

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宫腔粘连和子宫纵隔的宫腔镜手术预后与TGF-β1的关系

基础研究 | 更新时间：2024-01-17

- 宫腔粘连和子宫纵隔的宫腔镜手术预后与TGF-β1的关系
- Relationship between TGF-β1 expression and the prognostic of intrauterine adhesion and uterine septum after hysteroscopic surgery
- 重庆医科大学学报 2017年42卷第4期页码：389-393
- 作者机构：
  
  西安交通大学第二附属医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001228
  中图分类号： R713.4
- 纸质出版日期：2017，
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赵刚, 谢秀英, 薛翔. 宫腔粘连和子宫纵隔的宫腔镜手术预后与TGF-β1的关系[J]. 重庆医科大学学报, 2017,42(4):389-393.

Zhao Gang, Xie Xiuying, Xue Xiang. Relationship between TGF-β1 expression and the prognostic of intrauterine adhesion and uterine septum after hysteroscopic surgery[J]. Journal of Chongqing Medical University, 2017,42(4):389-393.
赵刚, 谢秀英, 薛翔. 宫腔粘连和子宫纵隔的宫腔镜手术预后与TGF-β1的关系[J]. 重庆医科大学学报, 2017,42(4):389-393. DOI： 10.13406/j.cnki.cyxb.001228.

Zhao Gang, Xie Xiuying, Xue Xiang. Relationship between TGF-β1 expression and the prognostic of intrauterine adhesion and uterine septum after hysteroscopic surgery[J]. Journal of Chongqing Medical University, 2017,42(4):389-393. DOI： 10.13406/j.cnki.cyxb.001228.

摘要

目的:探讨转化生长因子-β1（transforming growth factor-β1

TGF-β1）在宫腔粘连和子宫纵隔患者宫腔镜术后子宫内膜中的不同表达与预后之间的关系。方法:选取2014年6月至2015年5月在西安交通大学第二附属医院行宫腔镜手术的患者96例

其中宫腔粘连、子宫纵隔患者各48例

用免疫组化SP法检测TGF-β1在患者术后3周子宫内膜中的表达情况

术后3个月按NASR评分将宫腔粘连和子宫纵隔患者分为预后良好组、预后一般组和预后不良组

用方差分析及卡方检验分析各组数据之间的差异。结果:宫腔镜术后3个月

子宫纵隔手术预后优于宫腔粘连

差异有统计学意义（χ

=13.714

P=0.000）;免疫组化染色结果显示

在宫腔粘连患者中

TGF-β1在预后不良组中的表达水平（n=16

2.94±0.70）明显高于预后一般组（n=20

1.65±0.76）和预后良好组（n=12

1.08±0.79）

差异有统计学意义（P=0.000

P=0.000）

在预后一般组中的表达高于预后良好组

差异有统计学意义（P=0.045）;在子宫纵隔患者中

TGF-β1在预后不良组中的表达水平（n=6

2.58±0.97）明显高于预后一般组（n=12

1.25±0.54）和预后良好组（n=30

0.78±0.55）

差异有统计学意义（P=0.000

P=0.000）

在预后一般组中的表达高于预后良好组

差异有统计学意义（P=0.030）。结论:宫腔粘连和子宫纵隔宫腔镜手术预后差异可能与TGF-β1在子宫内膜中的异常表达有关

其预后不良可能与TGF-β1在子宫内膜中的过度表达有关。

Abstract

Objective:To investigate the relationship between transforming growth factor-β1（TGF-β1）expression in endometrium tissue of patients and the prognostic of intrauterine adhesions（IUA）and uterine septum after hysteroscopic surgery. Methods:Totally 96 cases of IUA and uterine septum diagnosed by hysteroscopy in the Second Affiliated Hospital of Xi’an Jiaotong University from June2014 to May 2015

including 48 cases of intrauterine adhesion and 48 cases of uterine septum. Data on the expression of TGF-β1 in the endometrium tissue three weeks after hysteroscopic surgery were detected by SP immunohischemistry staining. Those cases were divided into the good prognosis group

the acceptable prognosis group and the poor prognosis group depending on NASR score three month after hysteroscopic surgery. Relationship between the expression of TGF-β1 in the different groups were analyzed by chi-square test and ANOVA. Results:The prognosis of uterine septum surgery was superior to that of intrauterine adhesion three month after hysteroscopic surgery

with significant differences（χ

=13.714

P=0.000）. For IUA

the expression of TGF-β1 in poor prognosis group（n=16

2.94±0.70）was much higher than that of acceptable prognosis group（n=20

1.65±0.76）and good prognosis group（n=12

1.08±0.79）

with significant differences（P=0.000

P=0.000）. The expression of TGF-β1 in acceptable prognosis group was higher than that of good prognosis group

with significant differences（P=0.045）. For uterine septum

the expression of TGF-β1 in poor prognosis group（n=6

2.58±0.97）was much higher than that of acceptable prognosis group（n=12

1.25±0.54）and good prognosis group（n=30

0.78±0.55）

with significant differences（P=0.000

P=0.000）. The expression of TGF-β1 in acceptable prognosis group was higher than that of good prognosis group

with significant differences（P=0.030）. Conclusion:Aberrant expression of TGF-β1 in the endometrium tissue may have relationship with the different prognosis in IUA and uterine septum after hysteroscopic surgery

and overexpression of TGF-β1 in the endometrium tissue after hysteroscopic surgery may have relationship with its poor prognosis.

关键词

转化生长因子-β1子宫内膜组织宫腔粘连子宫纵隔宫腔镜检查预后

Keywords

transforming growth factor-β1endometrium tissueintrauterine adhesionsuterine septumhysteroscopyprognosis

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