Objective:To observe the efficacy of Jianpi Huazhuo San combined with metformin in the treatment for obese patients with type 2 diabetes mellitus. Methods:Totally 120 patients were randomly divided into treatment group（60 cases）and control group（60cases）. Patients in control group was treated with metformin while those in treatment group was treated with Jianpi Huazhuo San combined with metformin. The clinical efficacy and the following items before and after the therapy were observed and compared :fasting blood glucose（FBG）

postprandial 2h blood glucose（P2h BG）

glycosylated hemoglobin（Hb A1c）

fasting insulin（FINS）

body mass index（BMI）

insulin resistance index（HOMA-IR）. Results:After 3-month treatment

the blood glucose level and weight decreased effectively in both two groups. Dropping blood glucose level and reduced weight effective rate were 89.286%（50/56）

92.857%（52/56）in treatment group

obviously higher than those of 74.545%（41/55）

76.364%（42/55）in control group. The difference between the two groups was significant（P=0.026

P=0.047）. In the two groups after treatment

FBG

P2 h BG

Hb A1 c

FINS

HOMA-IR and BMI were decreased. The differences were statistically significant compared with before treatment（P=0.000）. Moreover

treatment group was more effectively than control group

with significant differences（P=0.000）. Conclusion:Jianpi Huazhuo San combined with metformin is effective in the treatment for obese patients with type 2 diabetes mellitus.