Objective:To investigate the effect of hypoalbuminemia on severity of coronary artery lesions and the prognosis in patients with acute ST-segment elevation myocardial infarction（STEMI）. Methods:A retrospective study was conducted in all hospitalized patients who were diagnosed as STEMI in 2014. According to the inclusion and exclusion criteria

all patients were divided into low serum albumin group（n=64）and normal serum albumin group（n=203）. The coronary angiography results were collected

and the mortality rate and incidence of major adverse cardiovascular events（MACE）followed up for 1 year after myocardial infarction were also analyzed. Results:Compared with normal albumin group

patients in low serum albumin group were older

with lower BMI and blood pressure on admission（P<0.05）. The latter group had higher KILLIP heart function classification

while exhibited higher incidence of triple vessel lesions（P=0.010）. In addition

patients with hypoalbuminemia had a greater all-cause mortality in 1 year after myocardial infarction

along with a much higher rate of MACE in 7 days（P=0.004;P=0.021）

however

the occurrence of bleeding events was comparable between the two groups（P=0.552）. Multiple Cox proportional hazard analysis showed that hyponatremia remained as an independent predictor for all-cause death of STEMI after multivariable adjustment（HR=2.610

95%CI=1.165 to 5.848

P<0.05）. Conclusion:Serum albumin level is of great value for assessing the severity of coronary artery lesions

and hypoalbuminemia is an independent risk factor for prognostic prediction of STEMI.