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1. 绵阳市中心医院肾内科
2. 重庆医科大学附属第一医院感染科
纸质出版日期:2017,
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汪嘉莉, 姚云清, 张奉莲, 等. 维持性腹膜透析患者颈动脉钙化的相关因素分析[J]. 重庆医科大学学报, 2017,42(2):232-235.
Wang Jiali, Yao Yunqing, Zhang Fenglian, et al. Carotid artery calcification and its relative factors in patients with maintenance peritoneal dialysis[J]. Journal of Chongqing Medical University, 2017,42(2):232-235.
汪嘉莉, 姚云清, 张奉莲, 等. 维持性腹膜透析患者颈动脉钙化的相关因素分析[J]. 重庆医科大学学报, 2017,42(2):232-235. DOI: 10.13406/j.cnki.cyxb.001147.
Wang Jiali, Yao Yunqing, Zhang Fenglian, et al. Carotid artery calcification and its relative factors in patients with maintenance peritoneal dialysis[J]. Journal of Chongqing Medical University, 2017,42(2):232-235. DOI: 10.13406/j.cnki.cyxb.001147.
目的:探讨维持性腹膜透析患者颈动脉钙化的相关危险因素。方法:入选绵阳市中心医院腹膜透析室稳定接受规律腹膜透析的患者100人
按照颈动脉是否钙化分为颈动脉钙化组(55例)
颈动脉正常组(45例)。收集患者临床资料
评估残余肾功能和透析充分性
采用彩超检查评估颈动脉有无钙化。用二元logistics回归法分析颈动脉钙化的独立危险因素。结果:2组患者比较:颈动脉钙化组较颈动脉正常组年龄(42.36±8.79 vs.34.93±9.60)岁、空腹血糖(6.91±0.44 vs.6.66±0.30)mmol/L、钙磷乘积(3.98±0.40 vs.3.82±0.30)mmol/L、甲状旁腺激素(parathyroid hormone
PTH)(270.72±30.24 vs.260.23±11.05)ng/L增加(P
<
0.05)
而残余肾功能(2.25±0.74 vs.5.14±1.07)m L/min、总肌酐清除率(creatinine clearance rate
Ccr)(59.92±3.94 vs.66.11±7.01)L/(周·1.73 m
2
)、残余肾Ccr(19.66±2.85 vs.25.07±6.53)L/(周·1.73 m
2
)、总尿素清除指数(urea clearance index
Kt/V)(4.06±0.51 vs.4.46±0.39)、残肾Kt/V(1.12±0.30 vs.1.45±0.28)较颈动脉正常组降低(P
<
0.05)。logistic回归分析显示:透析龄(OR=1.218
P=0.039)、钙磷乘积(OR=70.403
P=0.037)、残余肾功能(OR=0.030
P=0.001)、残肾Ccr(OR=0.692
P=0.015)是颈动脉钙化的影响因素。结论:行规律腹膜透析患者的颈动脉钙化发生率较高
透析龄长、高钙磷乘积和低残余肾功能是腹膜透析患者发生颈动脉钙化的独立危险因素。
Objective:To discuss the relative factors of carotid calcification in maintenance peritoneal dialysis patients. Methods:One hundred patients with maintenance peritoneal dialysis in the Central Hospital of Mianyang were involved and divided into carotid artery calcification group(55 cases)and the normal group(45 cases)according to whether having carotid artery calcification. Their general dialysis data were collected for the evaluation of dialysis adequacy and residual renal function. The calcification of carotid arteries was assessed by the color Doppler ultrasonography. The independent risk factors for carotid artery thickening and calcification were analyzed by binary logistic regression analysis. Results:Compared with those of normal group
the age(42.36±8.79 vs. 34.93±9.60)years
fasting blood glucose(6.91±0.44 vs. 6.66±0.30)mmol/L
calcium and phosphorus product(3.98±0.40 vs. 3.82±0.30)mmol/L
parathyroid hormone(270.72±30.24 vs. 260.23±11.05)ng/L in the carotid artery calcification group were increased(P
<
0.05)
while the residual renal function(2.25±0.74 vs. 5.14±1.07)m L/min
total creatinine clearance rate(Ccr)(59.92±3.94 vs. 66.11±7.01)L/(week·1.73 m
2
)
residual kidney Ccr(19.66±2.85 vs. 25.07±6.53)L/(week·1.73 m
2
)
urea clearance index(Kt/V)(4.06±0.51 vs.4.46±0.39)
residual kidney Kt/V(1.12±0.30 vs. 1.45±0.28)were decreased. Logistic regression analysis showed that dialysis age(OR=1.218
P=0.039)
the calcium-phosphorus product(OR=70.403
P=0.037)
the residual renal function(OR=0.030
P=0.001)and the residual kidney Ccr(OR=0.692
P=0.015)were associated with carotid intimal thickening and calcification. Conclusion:Carotid artery calcification is prevalent in maintenance peritoneal dialysis patients. Dialysis ages
calcium and phosphorus product
residual renal function are independent risk factors for carotid artery calcification.
腹膜透析颈动脉钙化颈动脉彩超
peritoneal dialysiscarotid artery calcificationcarotid color ultrasonography
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