Objective:To explore the association between norepinephrine transporter（NET）T182C polymorphism and depression by carrying out a meta-analysis based on published articles. Methods:Databases including Pub Med

Embase

Wan Fang（Chinese）

CNKI and CQVIP were searched for literature about norepinephrine transporter T182 C polymorphism and depression

and the data were analyzed by using STATA 12.0. OR

95% CI and P value were employed as the evaluation index to assess the association between T182 C polymorphism and risk of depression under four different genetic models. Results:Twelve studies of 3 056 cases and 2 861 controls meeting the inclusion criteria were enrolled in the Meta-analysis that. Significant association was observed between NET T182 C polymorphism and depression under allelotype model（OR=1.15

95%CI=1.04 to 1.28

P=0.009）

co-dominant model（OR=1.41

95%CI=1.04 to 1.90

P=0.026）

recessive model（OR=1.44

95%CI=1.13 to 1.85

P=0.004）;allele C or genotype CC increased the risk of depression. The sub-group analysis showed that employing the different evaluation scales for depression mainly resulted in the heterogeneity. Conclusion:NET T182 C polymorphism is related to the depression

and allele C may contribute to the risk of major depressive disorder.