Objective:To analyze the demographic characteristics and the potential influencing factors of adherence of colonoscopy screening among high-risk populations of colorectal cancer(CRC)in Chongqing China. Methods:The study was based on the "early detection and treatment of cancer project"in Chongqing. Totally 507 participants at high risk of CRC were selected to answer the colonoscopy screening questions. Multivariate stepwise logistic regression was used to determine which factors had a statistically significant effect on adherence of colonoscopyscreening. Results:Of the 507 participants

18.6% accepted the colonoscopy screening. Data from the multivariate logistic regression revealed that older people(OR=0.967

95%CI=0.937 to 0.998)who have family history of CRC(OR =0.182

95% CI =0.087 to 0.380) or consider himself at high risk of CRC(OR =0.495

95% CI =0.366 to 0.668) were more willing to accept the colonoscopy screening

while busy working(OR=8.879

95%CI=2.550 to 30.914)

fearing the pain of colonoscopy(OR=21.140

95%CI=4.841 to 92.313)and complicated bowel preparation(OR=22.849

95%CI=2.822 to 185.002)were independent barriers for colonoscopy screening. Conclusion:Effective intervention should be adopted to make people realize that they are at high risk of CRC. And at the same time health education program is needed to ease the fear of colonoscopy screening

thus improving colorectal colonoscopy screening adherence.