Objective:To compare the pharmacodynamics between 1% propofol and 2% propofol during anesthesia of patients with laparoscopic cholecystectomy. Methods:Totally 80 patients with laparoscopic cholecystectomy were randomly divided into two groups.Group Ⅰ was given target controlled infusion of 1% propofol(3μg/m L) for anesthesia induction and group Ⅱ was given 2%propofol(3 μg/m L)

auditory evoked potentials index(AAI)value was maintained below 30 during the whole procedures.The time of consciousness extinction

the time of AAI value decreasing to 30

average arterial pressure(MAP) mean decreasing percent

heart rate(HR) mean decreasing percent

dosage of propofol

dosage of propofol at 1 hour and the time of AAI value recuperating to 60 were recorded and assessed. Results:The time of AAI value decreasing to 30 was(194.75±84.81)s and(236.75±92.49)s in Ⅰ group and Ⅱgroup respectively(t=-2.04

P=0.04).The dosage of propofol was higher in Ⅱgroup[(12.20±2.60)m L] than in Ⅰ group[(9.97±2.64)m L](t=-3.45

P=0.00). The dosage of propofol at 1 hour was higher inⅡ group[(44.21±13.99)m L] than in Ⅰ group[(37.83±9.94)m L](t=-2.30

P=0.02). The total dosage of propofol was higher inⅡ group[(62.07±24.88)m L] than in Ⅰ group [(49.18±22.62)m L](t=-2.97

P=0.00). Conclusion:The potency of 1% propofol is stronger than 2% propofol.