Objective:To compare clinical characteristics of necrotizing enterocolitis(NEC)between pre-term and full-term neonates.Methods:Clinical data of 338 patients diagnosed as NEC(Bell’s stage ≥2) were retrospectively analyzed. Data including perinatal information

complications after NEC diagnosed

basic treatment after NEC diagnosed and risk factors of prognosis were compared between pre-term group(n=94)and term group(n=224). Results:The incidence of premature rupture of membranes was higher in preterm group(P<0.05);sepsis

respiratory failure were more likely happen in neonates after NEC diagnosed in pre-term group(P<0.05)

and rate of using dopamine

IVIG and infusion of red blood cells were higher in pre-term group(P<0.05). Logistic regression analysis discovered that risk factors for mortality in pre-term infants were sepsis(OR=3.78

95%CI=1.204 to 11.873

P=0.023)and NEC stageⅢ(OR=6.725

95%CI=2.153 to 21.01

P=0.001). While

the risk factors in full-term group were NEC stage Ⅲ(OR=7.762

95%CI=3.392 to 15.23

P=0.000). Conclusion:There are differences in prenatal factors

clinical complications

treatment measures and risk factors affecting prognosis between pre-term infants and full-term infants with NEC. Pre-term NEC patients have more complications than full-term infants. Sepsis and NEC stage Ⅲ are common risk factors for poor prognosis of pre-term and full-term NEC patients.Sepsis is an extra risk factor for poor prognosis of pre-term NEC patients.