Objective:To explore the predisposing perinatal environmental factors of food sensitization and allergy in infants with different allergic family histories. Methods:Totally 2 030 copies of questionnaires data from the epidemiological investigation of food allergy were analyzed retrospectively. Logistic regression was used to analyze the perinatal environmental risk factors of food sensitization and allergy in infants with different allergic family histories. Results:The incidence of food sensitization and allergy in positive allergic family history infants was significantly higher than that of negative family history infants(sensitization:27.1% vs. 15.3%

χ2=35.752

P=0.000;allergy:19.5% vs. 9.7%

χ2=34.472

P=0.000). 62.5% of food sensitization infants and 59.5% of food allergy infants were from family without allergic history. Logistic regression analysis showed that high protein intake during pregnancy might lead to food sensi-tization(OR=1.618

95%CI=1.085 to 2.414

P=0.018);no environmental risk factors was found for food allergy in infants with allergic family history. While

for infants without allergic family history

high birth weight

the earliest food intake during the first 3 days

high protein intake during pregnancy may increase the risk of occurrence of food sensitization

respectively(OR =1.674

95% CI =1.115 to 2.515

P=0.013;OR=1.396

95%CI=1.040 to 1.875

P=0.026;OR=1.996

95%CI=1.495 to 2.664

P=0.000);high birth weight

high protein intake during pregnancy were the risk factors of food allergy(OR=1.794

95%CI=1.104 to 2.916

P=0.018;OR=1.797

95%CI=1.269 to 2.546

P=0.001). Conclusion:Compared with the infants from negative allergic family history

those from positive family history are more susceptible to food sensitization and allergy. However

much attention should be paid to perinatal environment factors influencing food sensitization or allergy among infants without allergic family history. Therefore

different preventive strategies should be considered among individuals in clinic.