Objective:To investigate the association of ADAMTS1 gene single nucleotide polymorphisms with atherosclerotic coronary heart disease(CHD). Methods :This study includes 315 CHD and 355 control who admitted to the First Affiliated Hospital of Chongqing Medical University. SNP rs428785 and SNP rs2738 were detected by polymerase chain reaction-single-strand conformation polymorphism(PCR-SSCP)and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)

then verified by gene sequencing techniques. Chi-square test was used to analyze the count data

Mann-Whitney U test and independent-samples T test were used to analyze the measurement data between the two groups. Results:The genotype frequencies of SNP rs428785 in CHD group and the control group respectively were CC(50.2% vs. 38.9%)

CG(40.3% vs. 47.9%)and GG(9.5% vs. 13.2%);there was a great statistically significance between the two groups(χ~2=8.974

P=0.011)as well as the frequency of G allele(29.7% vs.37.2%;χ~2=8.410

P=0.004). After logistic regression analysis

CG+GG genotype of SNPrs428785 may be associated with CHD(0R=1.528

95%CI=1.086 to 2.150

P=0.015). SNP rs2738 in CHD group and the control group were AA(74.3% vs. 78.9%)

AC(24.1%vs. 18.9%)and CC(1.6% vs. 2.3%)respectively

but there was no statistically significance between the two groups(χ~2=2.998

P=0.223)

and there was also no significance in frequency of A allele(86.3% vs. 88.3%;χ~2=1.164

P=0.281). Conclusion:SNP rs428785 but not SNP rs2738 polymorphisms of the ADAMTS1 gene may be associated with CHD. The G allele of the SNP rs428785 may be a genetic risk factor for CHD.