4例中枢性尿崩症合并高渗高血糖综合征病例分析

唐能华; 杨琴; 李启富; 程庆丰; 杨淑敏; 龙崇荣

doi:10.13406/j.cnki.cyxb.001061

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4例中枢性尿崩症合并高渗高血糖综合征病例分析

论著 | 更新时间：2024-01-17

- 4例中枢性尿崩症合并高渗高血糖综合征病例分析
- Case analysis of 4 patients with CDI combined with HHS
- 重庆医科大学学报 2016年41卷第11期页码：1110-1112
- 作者机构：
  
  1. 重庆市沙坪坝区人民医院内分泌科
  2. 重庆医科大学附属第一医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001061
  中图分类号： R584.3;R587.1
- 纸质出版日期：2016，
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[1]唐能华,杨琴,李启富,程庆丰,杨淑敏,龙崇荣.4例中枢性尿崩症合并高渗高血糖综合征病例分析[J].重庆医科大学学报,2016,41(11):1110-1112.

Tang Nenghua, Yang Qin, Li Qifu, et al. Case analysis of 4 patients with CDI combined with HHS[J]. Journal of Chongqing Medical University, 2016,41(11):1110-1112.
[1]唐能华,杨琴,李启富,程庆丰,杨淑敏,龙崇荣.4例中枢性尿崩症合并高渗高血糖综合征病例分析[J].重庆医科大学学报,2016,41(11):1110-1112. DOI： 10.13406/j.cnki.cyxb.001061.

Tang Nenghua, Yang Qin, Li Qifu, et al. Case analysis of 4 patients with CDI combined with HHS[J]. Journal of Chongqing Medical University, 2016,41(11):1110-1112. DOI： 10.13406/j.cnki.cyxb.001061.

摘要

目的:与单纯性高渗高血糖综合征（hyperosmolar hyperglycemic syndrome

HHS）比较

探讨HHS合并中枢性尿崩症（central diabetes insipidus

CDI）患者的临床特点。方法:回顾分析近年来我院收治的单纯HHS患者11例（HHS组）以及CDI合并HHS 4例患者（合并组）的临床资料。结果:12组间性别、BMI、收缩压、舒张压、血BUN/Cr无统计学差异（P>0.05）

HHS组的平均年龄高于合并CDI组（P<0.05）。2与HHS组比较

入院时合并组的血糖、血钠、血渗透压、尿比重、尿渗透压均无统计学差异（P>0.05）。扩容后

2组血糖均明显下降

但合并组血钠及血渗透压显著高于HHS组（P<0.05）

尿比重及尿渗透压显著低于HHS组（P<0.05）。结论:单纯HHS与合并CDI的HHS患者临床表现和实验室检查有相似之处

当HHS患者补液、降血糖后高血钠未及时纠正

应考虑HHS合并CDI的可能。

Abstract

Objective:To investigate the clinical characteristics of hyperosmolar hyperglycemic syndrome(HHS)combined with central diabetes insipidus(CDI)in comparison with HHS. Methods:The clinical information of 11 patients diagnosed with HHS(HHS group)and 4 patients diagnosed with CDI combined with HHS(combination group)were retrospectively analyzed. Results:1There was no difference in sex

BMI

SBP

DBP and BUN/Cr between the two groups(P>0.05)

while the mean age of HHS group was higher than that of the combination group(P<0.05). 2When admitted to the hospital

the blood glucose

serum sodium

serum osmolality

urine specific gravity and urine osmolality of the patients in the combination group has no difference compared with those of HHS group(P>0.05). After rehydration therapy

the blood glucose decreased in both groups. However

in the combination group

the serum sodium and osmolality were significantly higher than that of HHS group(P>0.05);the urine specific gravity and urine osmolality were obviously lower than that of HHS group(P>0.05). Conclusion:The clinical manifestations and laboratory investigations in patients who suffered from HHS combined with CDI are similar to those with HHS only. When the hypernatremia in HHS patients can’t be improved effectively after the rehydration and hypoglycemic therapy

we should take the HHS combined with CDI into consideration.

关键词

中枢性尿崩症高渗高血糖综合征高钠血症尿比重尿渗透压

Keywords

central diabetes insipidushyperosmolar hyperglycemic syndromehypernatremiaurine specific gravityurine osmolality

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