Objective:To reveal the effect of the interaction between Gly1057 Asp polymorphism of insulin receptor substrate 2(IRS2)and environment on the susceptibility of type 2 diabetes(T2DM). Methods:The case-report research was performed on 467 patients with T2 DM and 305 normal controls who belong to Chinese Han population from Chongqing. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing technology genotyped the Gly1057 Asp. The interaction between Gly1057 Asp and the environments including age

obesity and hypertriglyceridemia

were analyzed by the multifactor dimensionality reduction software(MDR). Results:The susceptibility of T2 DM in the persons with GG of Gly1057 Asp was 1.42 times higher than those with AA genotype(OR=1.422

95%CI=1.037~1.949

P=0.029). MDR analysis showed that Gly1057 Asp

age

waist and plasma triglyceride level consisted the four-factor interaction model(P=0.001). GG or GA of Gly1057 Asp increased in the risk of T2 DM of the subjects beyond 60 years old or with abdominal obesity. The subjects with abdominal obesity and hypertriglyceridemia were susceptible to T2 DM

excepting those with AA genotype and between 40 to 60 years old(OR=3.342

95%CI=1.168~9.561

P=0.026). Conclusion:The persons with the GG of Gly1057 Asp in IRS2

abdominal obesity and hypertriglyceridemia together

may be much higher susceptible to T2 DM in Chinese Han population from Chongqing.