Objective:To investigate the radiologic

histologic

and immunohistochemical features of primary hepatic large B-cell lymphoma(PHLBL)and to explore its clinicopathologic features

diagnosis

differential diagnosis

treatment

and prognosis. Methods:Five cases of PHLBL were evaluated by histology and immunohistochemistry;the in situ hybridization was also employded to detect the EBV-encoded small RNA(EBER). The related literature was reviewed as well. Results:The 5 patients

with the average age of 63.5years

presented symptoms of upper-right abdominal distension

athrepsia

and anemia. Contrast CT scan indicated uneven enhancement in the focus. Histologically

the indistinct tumor cells showed diffused proliferation and were large in size with ample cytoplasm and overt nucleolus. Mitoses were easily observed. Immunohistochemically

the tumor cells were diffusely positive for CD19

CD20

and CD79 a

but negative for CD3 and CD43.The proliferative index of Ki67 was 75% to 80%. Conclusion:PHLBL is rare with poor prognosis. Liver biopsy and immunohistochemical stainings are helpful for its diagnosis. It should be differentiated from metastastic lymphoma involving the liver. Early surgery and chemotherapy could obtain good effect.