Objective:To evaluate the effects of hormonal replacement therapy（HRT）on lipid in postmenopausal women by metaanalysis. Methods:Databases of Pub Med

Ovid and Embase were searched from January 1985 to December 2012. Randomized controlled trials（RCTs）assessing the efficacy of different HRT for cardiovascular diseases（CVD）in postmenopausal women were collected. Pooled odds ratio（OR）with the 95% confidence interval（CI）was calculated using random-effect or fixed-effect model when appropriate.Total cholesterol（TC）

high density lipoprotein cholesterol（HDL-C）

low density lipoprotein cholesterol（LDL-C）

triglycerides（TG）

homocysteine（HCY）were used based on Cochrane’s recommend. Results:Twenty-two RCTs involving a total of 1 507 premenopausal or postmenopausal women were included in the meta-analysis.Three group were divided:transdermal HRT group

control 1 group（oral HRT）

control 2 group（blank control group）.Levels of TC and HCY were decreased significantly in transdermal HRT group than in control 2 group（MD=0.29

95%CI=0.03 to 0.55

P=0.030）

（MD=0.71

95%CI=0.10 to 1.32

P=0.020）. Levels of HDLC（MD=-0.02

95%CI=-0.13 to 0.09

P=0.750）and TG（MD=-0.02

95%CI=-0.11 to 0.06

P=0.590）were not significantly changed in transdermal HRT group and control 1 group. Levels of LDL-C were decreased significantly in transdermal HRT estrogen-only subgroup（MD=0.31

95%CI=0.13 to 0.48

P=0.001）. There was no significant change in level of TC

LDL-C

TG and HCY between transdermal HRT group and control 1 group（MD=0.03

95%CI=-0.14 to 0.20

P=0.730）

（MD=-0.04

95%CI=-0.13 to 0.04

P=0.270）

（MD =0.05

95% CI =-0.16 to 0.26

P =0.650）

（MD =0.32

95%CI=-0.47 to 1.11

P=0.420）. Levels of HDL-C（MD=0.01

95%CI=-0.10 to 0.12

P=0.860）were not significantly changed

but in estrogen-only subgroup

levels of HDL-C were decreased obviously

and there were significantly statistic differences between transdermal HRT group and control 1 group（MD=0.19

95%CI=0.10

0

.28

P=0.000）. Conclusion:There is no difference between transdermal HRT and oral HRT concerning lipid and HCY. Compared with females do not receive HRT

females had transdermal HRT had better lipid and HCY;therefore transdermal HRT may be conducive to preventing CVD.