Objective:To select the appropriate period of treatment for patients with hyperlipidemic pancreatitis(HLP)based on conventional therapy with hemoperfusion and continuous veno-venous hemofiltration. Methods:A retrospective study was performed on the clinical data of 49 HLP patients between January 2011 and March 2014. All included patients were divided into 3 groups based on the time they start to receive the blood purification. Eleven patients in group A began CBP treatment within 4 hours after disease onset. Group B containes 29 cases undergoing CBP treatment between 72 hours and 120 hours. Six patients in group C underwent CBP treatment after 120 hours. Acute physiology and chronic health evaluation Ⅱ(APACHEII)score

C-reactive protein(CRP)

hematocrit(Hct)

triglyceride(TG)

total cholesterol(TC)

serum creatinine(SCr)

alanine aminotransferase(ALT)

Pa O2/Fi O2 and average length of stay were observed and recorded before and after treatment. Results:After treatment

APACHE Ⅱ score

CRP

Hct

TG

TC

SCr

ALT of group A and group B were decreased

and Pa O2/Fi O2 of group A and group B were elevated;but there was no statistical significant difference in above indexes before and after treatment in group C(P >0.05). APACHE Ⅱ score

CRP

SCr

ALT

Pa O2/Fi O2 were changed more significantly in group B

while no difference in Hct

TG and TC was observed between group A and group B(P >0.05)after treatment

which shows that undergoing HP and CVVH in the early stage can effectively decrease blood lipid level and relief systemic inflammatory response. Peak period of systemic inflammatory response was between 4 hours and 72 hours. As to average length of stay

group B was the shortest. Conclusion:Except the conventional is necessary to start HP and CVVH treatment between 4~72 hours after disease onset for HLP patients.