Objective:To systematically evaluate the efficacy and safety of lipid emulsion in the early treatment of the very low birth weight premature infants. Methods:The Pub Med

Cochrane Central Register of Controlled Trials

MEDLINE

EMBASE

OVID

Chinese biomedical literature database(CBM)

CNKI

VIP

and Wan fang databases journals were searched up to March 2015 to collect the English and Chinese literature about randomized controlled trials(RCTs)of lipid emulsion in the early treatment of the very low birth weight premature infants. The reviewers screened the literature

extracted the data

and assessed the quality according to the method of Jadad’s Scale

and conducted Meta-analysis with Rev Man5.2 software. Results:A total of 13 RCTs were included

including 852patients(experimental group: 440 patients

control group:412 patients). Meta-analysis showed that the recovery of birth weight in the experimental group was shorter than that in the control group(MD =-3.09

95% CI =-3.58 to-2.60

P <0.000 01). There was no significant differences in the incidence of necrotizing enterocolitis(NEC)(RR=0.66

95%CI=0.33 to 1.32

P=0.24)

sepsis(RR=0.85

95%CI=0.72 to 1.00

P=0.05)

jaundice(RR=1.03

95%CI=0.84 to 1.25

P=0.78)

mortality during hospitalization(RR=0.93

95%CI=0.70 to 1.22

P=0.59)

hypertriglyceridemia(RR=1.24

95%CI=0.75 to 2.04

P=0.41)

hypoglycemia(RR=1.55

95%CI=0.82 to 2.92

P=0.17)and bronchopulmonary dysplasia(BPD)(RR=0.92

95%CI=0.70 to 1.20

P=0.53)between the two groups. Conclusion:Early lipid emulsion(≤2 d)is a safe and effective treatment for the very low birth weight premature infants

which can shorten the time of recovery of the birth weight without increasing the incidence of other adverse reactions.