Objective:To discuss the efficacy of Billroth Ⅱ and ROUX-en-Y anastomosis for type 2 diabetes mellitus(T2DM)patients with gastric diseases underwent subtota gastrectomy. Methods:Totally 116 patients with T2 DM underwent subtota gastrectomy in our hospital from August 2012 to August 2014 were selected

and were divided into A group(Billroth Ⅱ group

60 cases)and B group(ROUX-en-Y group

56 cases). The level of fasting blood glucose(FBG)

postprandial blood glucose(PBG)

hemoglobin Alc(Hb Alc)

insulin resistance index(IRI)at different observation time points and clinical effect were compared between two groups. Results:In A group and B group at 1

3

6 months after operation

the FBG levels were(7.85±2.04)vs.(7.04±1.93)

(7.75±1.82)vs.(6.84±1.83)

(7.81 ±1.95) vs.(6.72 ±1.74) respectively;the PBG levels were(12.26 ±2.30) vs.(11.15 ±2.28)

(12.12 ±2.41) vs.(10.74±2.52)

(11.56±2.37)vs.(10.48±2.32)respectively;the Hb Alc levels were(7.46±2.56)vs.(7.92±2.40)

(7.61±2.79)vs.(6.67±2.14)

(7.39±1.91)vs.(6.55±2.24)respectively;the IRI were(6.46±2.29)vs.(5.49±2.35)

(5.86±1.72)vs.(4.44±1.96)

(5.45±1.40)vs.(4.05±1.89)respectively. The results of ANOVA for repeated measurement showed that there were significant differences among FBG

PBG and IRI at different groups

different time points

different interaction between groups and time points(P<0.05). But Hb Alc showed significant differences at different time points(P<0.05). The total good rate of A group were significantly lower than that of B group(61.67% vs. 78.57%

P<0.05). Conclusion:Billroth Ⅱ and ROUX-en-Y anastomosis have certain clinical effect on T2 DM

and ROUX-en-Y anastomosis is superior to Billroth Ⅱ anastomosis. But the mechanism of the treatment is not clear

so the safety and feasibility of Billroth Ⅱ and ROUX-enY anastomosis for T2 DM needs further study.