Objective:To investigate the clinical value of minimally invasive puncture and drainage(MIPD)combined with Alteplase treatment in elderly patients with basal ganglia intracerebral hemorrhage(ICH). Methods:A retrospective analysis was made on 96 spontaneous basal ganglia ICH cases. Fifty cases received MIPD combined with Alteplase treatment(MIPD group)and 46 cases received conventional craniotomy and evacuation of hematoma(CC group). The Glasgow coma scale(GCS)scores

rebleeding incidences

postoperative complications(PC)

and hospital stay at one month after operation were compared between the two groups. Moreover

Glasgow outcome scale(GOS)

modified Rankin scale(m RS)

Barthel index(BI)

and case fatality(CF)at one year postoperation were assessed

respectively. Results:Compared with those of CC group

a significant decrease in rebleeding incidences

postoperative complications and hospital stay was observed in MIPD group at one month postoperation(P<0.05). Moreover

GCS score in MIPD group was obviously higher than that in CC group(P<0.05). The GOS

m RS

and BI representing long-term outcome in MIPD group were ameliorated significantly higher than that in CC group at one year postoperation(P<0.05). However

there was no significant difference between in CF between MIPD group and CC group(P >0.05). Conclusion:MIPD combined with Alteplase therapy may be an effective treatment in elderly patients with spontaneous basal ganglia ICH

which can improve the quality of life of patients by reducing the complications and mortality and ameliorating the neurological dysfunction.