首次<sup>131</sup>I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析

许璐; 庞华; 刘琼; 管丽丽; 王洁; 李文波

doi:10.13406/j.cnki.cyxb.000884

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首次¹³¹I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析

临床研究 | 更新时间：2024-01-17

- 首次¹³¹I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析
- Influencing factors of the curative efficacy of the first ¹³¹I radiotherapy for children and adolescents with differentiated thyroid carcinoma
- 重庆医科大学学报 2016年41卷第5期页码：480-484
- 作者机构：
  
  重庆医科大学附属第一医院核医学科
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上资助项目（编号:81071171）
- DOI：10.13406/j.cnki.cyxb.000884
  中图分类号： R736.1
- 纸质出版日期：2016，
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[1]许璐,庞华,刘琼,管丽丽,王洁,李文波.首次~(131)I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析[J].重庆医科大学学报,2016,41(05):480-484.

Xu Lu, Pang Hua, Liu Qiong, et al. Influencing factors of the curative efficacy of the first ¹³¹I radiotherapy for children and adolescents with differentiated thyroid carcinoma[J]. Journal of Chongqing Medical University, 2016,41(5):480-484.
[1]许璐,庞华,刘琼,管丽丽,王洁,李文波.首次~(131)I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析[J].重庆医科大学学报,2016,41(05):480-484. DOI： 10.13406/j.cnki.cyxb.000884.

Xu Lu, Pang Hua, Liu Qiong, et al. Influencing factors of the curative efficacy of the first ¹³¹I radiotherapy for children and adolescents with differentiated thyroid carcinoma[J]. Journal of Chongqing Medical University, 2016,41(5):480-484. DOI： 10.13406/j.cnki.cyxb.000884.

摘要

目的:讨论儿童及青少年分化型甲状腺癌（differentiated thyroid carcinoma

DTC）患者手术后首次放射性碘（radioiodine

RAI）治疗清除残余甲状腺组织的疗效的影响因素。方法:回顾性分析首次接受大剂量清除残余甲状腺组织治疗的患者88例

分为清甲治疗成功组与未成功组

对数据进行秩和检验、卡方检验或Fisher确切率法筛选影响因素

并做logistics回归分析。结果:用单因素分析筛选出治疗前甲状腺摄碘率（radioactive iodine uptake

RAIU）、淋巴结转移、肺转移是影响首次清甲治疗疗效的因素。多因素分析提示RAIU及淋巴结转移为影响首次清甲治疗疗效的独立影响因素。结论:儿童及青少年分化型甲状腺癌患者首次清甲治疗疗效的影响因素有RAIU、淋巴结转移、肺转移

其中RAIU、淋巴结转移的影响更为明显。

Abstract

Objective:To investigate the influencing factors of the curative efficacy for the first 131 I ablation therapy for thyroid remnant and metastatic lesions in children and adolescents with differentiated thyroid carcinoma(DTC). Methods:Based on the clinical data of 88 child and adolescent DTC cases(56 cases in complete-ablation group and 32 cases in incomplete-ablation group) of first 131 I ablation. Influencing factors were analyzed(rank-sum test

χ2-test

Fisher exact test)and logistic regression analysis were performed. Results:For the first 131 I ablation effectiveness in children and adolescents DTC patients

radioactive iodine uptake(RAIU)

lymph nodes metastases and lung metastases were selected as influencing factor. After logistic regression analysis

RAIU and lymph nodes metastases were independent parameters.Conclusion :Influencing factors of success rate of the first 131 I ablation therapy in children and adolescents DTC patients include RAIU

lymph nodes metastases and lung metastases

while independent parameters are RAIU and lymph nodes metastases.

关键词

儿童及青少年分化型甲状腺癌碘放射性同位素影响因素

Keywords

children and adolescentsdifferentiated thyroid carcinomaradioiodineinfluencing factor

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首次131I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析

Influencing factors of the curative efficacy of the first 131I radiotherapy for children and adolescents with differentiated thyroid carcinoma

DOI：10.13406/j.cnki.cyxb.000884

摘要

Abstract

关键词

Keywords

references

首次¹³¹I治疗儿童及青少年术后分化型甲状腺癌疗效的影响因素分析

Influencing factors of the curative efficacy of the first ¹³¹I radiotherapy for children and adolescents with differentiated thyroid carcinoma