Malignant melanoma is the most aggressive form of skin cancer and it is difficult to treat. The incidence of melanoma has been continuously increasing. Studies have shown that melanoma growth was inhibited by nanosecond pulsed electric fields(ns PEFs)treatment by inducing apoptosis and suppressing angiogenesis. Furthermore

ns PEFs treatment can stimulate immune response and inhibit tumor metastasis. The advantages of ns PEFs therapy are non-thermal

high-limited

almost no scarring and even no side effect. In recent years

the studies about ns PEFs treatment of melanoma are increasing. Therefore

in order to provide more evidence for subsequent research and clinical application

the efficiency

safety and treatment mechanism of ns PEFs therapy are reviewed here.