Objective:To investigate the efficacy of sequential non-invasive following short-term invasive mechanical ventilation in severe obstetric patients. Methods:Totally 47 patients in obstetric ICU using sequential non-invasive following short-term invasive mechanical ventilation were enrolled(sequential group);42 patients in obstetric ICU using invasive mechanical ventilation were enrolled(control group). Basic vital signs and disease classification were recorded before mechanical ventilation. Statistical analysis was made to compare the prognostic indicators and the incidence of complications between two groups. Results:Sequential group and control group had the same baseline in general. Intra-hospital mortality

invasive ventilation time

time in ICU and incidence of VAP were significantly lower in sequential group than in control group(P<0.05). Conclusion:Sequential non-invasive following short-term invasive mechanical ventilation could improve prognostic indicators and complications significantly for severe patients in obstetric department;it can effectively improve the therapeutic effect

therefore has broad clinical application prospects.