Diabetic encephalopathy(DE)is one of the most severe complications of diabetes. By far

it has been acknowledged that diabetes is one of the independent risk factors for cognitive dysfunction. However

the definition of DE remains controversial. The known risk factors for DE include hyperglycemia

lipid disorder

insulin-resistance

vascular diseases and obesity etc.

further resulting in abnormality of cerebral electro-neurophysiology

radiological and pathologic change

ultimately leading to chronic

progressive cognitive dysfunction.