隐匿性乙肝与肝细胞肝癌关系的系统评价

郑洁; 曾爱中

doi:10.13406/j.cnki.cyxb.000806

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隐匿性乙肝与肝细胞肝癌关系的系统评价

肿瘤诊断与治疗 | 更新时间：2024-01-17

- 隐匿性乙肝与肝细胞肝癌关系的系统评价
- Association between occult hepatitis B virus infection and the risk of hepatocellular carcinoma:a systematic review
- 重庆医科大学学报 2015年40卷第11期页码：1445-1449
- 作者机构：
  
  重庆医科大学附属第一医院感染科、重庆市传染病寄生虫病学重点实验室
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目（编号:30972587）
- DOI：10.13406/j.cnki.cyxb.000806
  中图分类号： R512.62;R735.7
- 纸质出版日期：2015，
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[1]郑洁,曾爱中.隐匿性乙肝与肝细胞肝癌关系的系统评价[J].重庆医科大学学报,2015,40(11):1445-1449.

Zheng Jie, Zeng Aizhong. Association between occult hepatitis B virus infection and the risk of hepatocellular carcinoma:a systematic review[J]. Journal of Chongqing Medical University, 2015,40(11):1445-1449.
[1]郑洁,曾爱中.隐匿性乙肝与肝细胞肝癌关系的系统评价[J].重庆医科大学学报,2015,40(11):1445-1449. DOI： 10.13406/j.cnki.cyxb.000806.

Zheng Jie, Zeng Aizhong. Association between occult hepatitis B virus infection and the risk of hepatocellular carcinoma:a systematic review[J]. Journal of Chongqing Medical University, 2015,40(11):1445-1449. DOI： 10.13406/j.cnki.cyxb.000806.

摘要

目的:评估隐匿性乙肝（occult Hepatitis B Virus infection

OBI）是否会增加肝细胞肝癌（hepatocellular carcinoma

HCC）发生的风险。方法:2个独立的研究者分别在Medline、web of science、web of knowledge、cochrane library、Embase、Biomed Central、Elton B.Stephens.Company（EBSCO）、中国生物医学文献数据库、中国学术期刊全文数据库、万方数据库和维普中文科技期刊全文数据库中检索文献

截止搜索日期2015年4月14日

根据纳入、排除标准筛选研究隐匿性乙肝与肝细胞肝癌关系的前瞻性队列研究或病例对照研究

并对纳入文献进行质量评价和数据提取

用Review manager 5.3软件对纳入的研究进行Meta分析

并进一步分别就OBI与隐源性HCC和非显性乙肝、丙肝相关性肝细胞肝癌（hepatitis B virus surface antigen negative and antiHCV negative hepatocellular carcinoma

NBNC-HCC）的关系作了Meta分析。结果:本研究最终筛选出8个符合条件的研究

有7个回顾性研究和1个前瞻性研究。回顾性研究的Meta分析纳入的7个研究总共有1 945个对象

其中HCC有561个

因7个研究异质性较大（I2=60%）

排除一个研究后

最终Meta分析结果表示OBI会增加HCC发生的风险

有统计学意义

比值比（odds ratio

OR）=9.28

95%可信区间（confidence interval

CI）=7.01

2.29

0.001

异质性χ2=5.61

自由度（degree of freedom

df）=5

P=0.35

I2=11%。结论:本研究发现的情况表明OBI会增加HCC发生的风险

对临床有一定的指导意义。

Abstract

Objective:To assess whether occult hepatitis B virus infection(OBI)can increase the risk of hepatocellular carcinoma(HCC). Methods:Literatures in relevant databases:Medline

Web of Science

Web of Knowledge

Cochrane library

Embase

Biomed Central

Ebsco

Chinese Biomedical Literature

China National Knowledge Internet

Wanfang Data and VIP were searched by two independent reviewers. The endline is April 14 th

2015. Prospective cohort studies or case-control studies about OBI and HCC were screened out by inclusive and exclusive criteria. Quality of the included literature was evaluated and data were extracted. Review Manager 5.3software was used for Meta analysis. Further more

Meta analysis of OBI between cryptogenic HCC and HBs Ag negative and anti-HCV negative HCC was conducted respectively. Results:Eight researches were screened out in this study finally

including seven retrospective studies and one prospective study. Seven retrospective studies of 1 945 patients were included in our study

and 561 hepatocellular carcinomas were included. Meta-analysis results indicated that OBI can increase the risk of HCC(OR=9.28

95%CI=7.01 to 12.29

P<0.001

heterogeneity(χ2=5.61

df=5(P=0.35);I2=11%)after excluding one study because of heterogeneity. There was no statistical difference in other side effects between the two groups(P >0.05). Conclusion:OBI can increase the risk of HCC

which is of clinical guiding significance.

关键词

隐匿性乙肝肝细胞肝癌比值比Meta分析

Keywords

occult hepatitis B virus infectionhepatocellular carcinomaodds ratioMeta analysis

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