Objective:To provide evidence for decision-making on lung cancer prevention through studying the risk between chronic obstructive pulmonary diseases(COPD) and lung cancer among nonsmokers. Methods :A literature search was conducted in Pub Med

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CNKI and Wang Fang to select the relevant publications on the association between chronic obstructive pulmonary diseases and lung cancer among nonsmokers. Quality of enrolled literatures was assessed and software of Review Manager 5.3 was employed to conduct Meta analysis. Results:Nine studies(2 089 cases and 4 519 controls)were identified. The morbidity rate of chronic obstructive pulmonary diseases was significantly different between lung cancer patients and controls

the pooled odd ratio was1.46(95%CI=1.26 to 1.70). The difference was obvious in White population(OR=1.58;95%CI=1.20 to 2.08)

but there was no statistical difference in Asian population(OR=1.25;95%CI=0.98 to 1.59). COPD was significantly associated with the odds for increased risk of lung cancer(pooled OR=1.46;95%CI=1.04 to 2.03)

so were chronic bronchitis(OR =1.64;95% CI =1.15 to 2.36) and emphysema(OR=1.47;95%CI=1.17 to 1.83). Conclusion:The morbidity of COPD is probably associated with lung cancer smoking.