Objective:To develop a biodegradable scaffold with a certain mechanical strength

osteoconduction and good cytocompatibility and biocompatibility by adjusting the proportion of beta-tricalcium phosphate(β-TCP)in Poly(L-lactic acid)(PLLA)/β-TCP composited porous scaffolds. Methods:The PLLA/β-TCP composited porous scaffolds

in which the content of β-TCP was respectively0%

10%

20%

30%

40%

50%

was synthesized by Solvent self diffusion-molding-salt leaching and freeze-drying method. Its microstructure

porosity

mechanical properties

cytocompati-bility and biocompatibility were studied. Results:PLLA is hydrophobic material and its scaffold is bad for cell adhesion. PLLA / β- TCP composited porous scaffold has rough surface;the addition of β- TCP can improve the hydrophilicity and osteoconduction of scaffold

which is good for cell crawl. In all groups

the P/T30 group scaffold had the largest number of crawling cells. The composite scaffold mixingβ-TCP has good X-ray imaging

which can provide convenience for in vitro X ray assessing the degradation of scaffold in vivo.PLLA/β-TCP composited porous scaffolds have reliable cytocompatibility and biocompatibility. Conclusion:The PLLA/β-TCP composited scaffolds fabricated by Solvent self diffusion-molding-salt leaching and freeze-drying method have rich porosity

certain mechanical strength

osteoconduction and good cytoco-mpatibility and biocompatibility. It is hopeful to obtain an ideal tissue engineered bone scaffold with adjustable degradation rate by adjusting the composition proportion.