Objective:To study the correlative factors in operation of pituitary adenoma invading the skull base bone. Methods:Clinical

imaging and pathological data of 227 patients were collected from January 2013 to January 2014 in our department of neurosurgery.The patients were divided into two groups:the invasive bone group(63 cases) and the noninvasive bone group(164 cases) based on the CT image.All data of two groups were comparatively analyzed and the correlation with eroding bone was analyzed by logistic regression. Results:Time of operation

amount of bleeding

the morbidity rate of complication and the positive expression of ki-67 protein in invasive bone group were(154.02±56.67) min

(219.84±250.57) ml

42.4%(42/99) and 47.4%(27/57) respectively

which significantly higher than those in noninvasive group[(124.35±42.75) min

(128.66±116.9) ml

10.9%(18/164) and 26.4%(28/106)].The risk factor of eroding the skull base bone was non-functional adenomas(OR=2.219

P=0.023)

giant adenoma(OR=18.63

P=0.031)

the hard adenoma(OR =2.915

P =0.032) and the adenoma with Knosp-Steiner grade of 4(OR =6.228

P =0.007). The incidence rate(32%) of bony invasion in non-functional pituitary adenomas was significantly higher than that in functional pituitary adenomas. Conclusion :Bony invasion of pituitary adenoma makes the surgery more difficult

which occurs more common in non-functional pituitary adenoma.Non-function

giant size

tough quality and Knosp grade 4 of pituitary adenoma are the risk factors for invading the bone of skull base.