尿液硫酸化胆汁酸代谢轮廓分析在无症状高胆汁酸血症识别中的应用

杨婷; 陈建波; 冯成亚; 崔悦; 李育超; 邵勇; 丁敏

doi:10.13406/j.cnki.cyxb.000646

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尿液硫酸化胆汁酸代谢轮廓分析在无症状高胆汁酸血症识别中的应用

基础研究 | 更新时间：2024-01-17

- 尿液硫酸化胆汁酸代谢轮廓分析在无症状高胆汁酸血症识别中的应用
- Asymptomatic hypercholanaemia of pregnancy identification based on metabolic profiling of urinary sulfated bile acid
- 重庆医科大学学报 2015年40卷第11期页码：1461-1464
- 作者机构：
  
  1. 重庆医科大学检验医学院临床检验诊断学教育部重点实验室
  2. 昆明金域医学检验所有限公司昆明市医学实验诊断技术中心
  3. 重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目（编号:81401228;81471473）;教育部高等学校博士学科点专项科研基金（博导类）资助项目（编号:20115503110013）
- DOI：10.13406/j.cnki.cyxb.000646
  中图分类号： R446.1;R714.25
- 纸质出版日期：2015，
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[1]杨婷,陈建波,冯成亚,崔悦,李育超,邵勇,丁敏.尿液硫酸化胆汁酸代谢轮廓分析在无症状高胆汁酸血症识别中的应用[J].重庆医科大学学报,2015,40(11):1461-1464.

Yang Ting, Chen Jianbo, Feng Chengya, et al. Asymptomatic hypercholanaemia of pregnancy identification based on metabolic profiling of urinary sulfated bile acid[J]. Journal of Chongqing Medical University, 2015,40(11):1461-1464.
[1]杨婷,陈建波,冯成亚,崔悦,李育超,邵勇,丁敏.尿液硫酸化胆汁酸代谢轮廓分析在无症状高胆汁酸血症识别中的应用[J].重庆医科大学学报,2015,40(11):1461-1464. DOI： 10.13406/j.cnki.cyxb.000646.

Yang Ting, Chen Jianbo, Feng Chengya, et al. Asymptomatic hypercholanaemia of pregnancy identification based on metabolic profiling of urinary sulfated bile acid[J]. Journal of Chongqing Medical University, 2015,40(11):1461-1464. DOI： 10.13406/j.cnki.cyxb.000646.

摘要

目的:探讨尿液硫酸化胆汁酸代谢轮廓分析在识别无症状高胆汁酸血症（asymptomatic hypercholanaemia of pregnancy

AHP）中的应用价值。方法:应用高效液相色谱-串联质谱法（HPLC-MS/MS）测定正常孕妇（13例）

妊娠肝内胆汁淤积症（intrahepatic cholestasis of pregnancy

ICP）（17例）尿液硫酸化胆汁酸谱

采用不同扫描模式鉴别和分析尿液各种硫酸化胆汁酸

并用主成分分析法（principle component analysis

PCA）对尿液硫酸化胆汁酸代谢轮廓进行分析。结果:采用不同的扫描模式对尿液中15种可能的硫酸化胆汁酸进行鉴定并分析

经PCA对尿液硫酸化胆汁酸代谢轮廓分析

发现在ICP组中存在一类特殊的人群

其表现为无任何症状的胆汁酸水平升高而肝功能正常

但其尿液硫酸化胆汁酸代谢轮廓与正常孕妇类似。结论:尿液硫酸化胆汁酸代谢轮廓分析有助于AHP的识别。

Abstract

Objective:To investigate the feasibility of metabolic profiling of urinary sulfated bile acid in intrahepatic cholestasis of pregnancy(ICP) identification. Methods:High performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) was employed to determinate urinary sulfated bile acids in 13 healthy pregnant women and 17 patients with ICP. Multiple scanning modes were used to identify and analyze possible sulfated bile acids in urine. Datas were analyzed by principle component analysis(PCA).Results:Fifteen possible urinary sulfated bile acids were identified and analyzed by multiple scanning modes. The PCA results showed that the existence of a special crowd in ICP group whose symptoms were elevated bile acids with normal liver function. While the changes in matabolic profiling of urinary sulfated bile acids in asymptomatic hypercholanaemia of pregnancy were resembled those described in healthy pregnant women. Conclusion:Metabolic profiling analysis of urinary sulfated bile acid is helpful for identification of asymptomatic hypercholanaemia of pregnancy.

关键词

无症状高胆汁酸血症妊娠肝内胆汁淤积症代谢轮廓分析硫酸化胆汁酸

Keywords

asymptomatic hypercholanaemia of pregnancyintrahepatic cholestasis of pregnancymetabolic profiling analysisurinary sulfated bile acids

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