浏览全部资源
扫码关注微信
结肠癌组织TLR4、CHI3L1表达与根治术后预后的关系
Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery
- 局解手术学杂志 2024年33卷第10期 页码：863-866
- 作者机构：
1.秦皇岛市第一医院肛肠外科，河北 秦皇岛 066000
2.秦皇岛市第一医院麻醉科，河北 秦皇岛 066000
3.秦皇岛市第一医院质量管理处，河北 秦皇岛 066000
- 作者简介：
许曦鸣，E-mail：15903351430@163.com
- 基金信息：秦皇岛市科学技术研究与发展计划(202101A123)
DOI：10.11659/jjssx.10E023038
中图分类号： R735.3纸质出版日期：2024-10-25，
收稿日期：2023-10-10，
- 稿件说明：
移动端阅览
宋春光,牛志新,何峰等.结肠癌组织TLR4、CHI3L1表达与根治术后预后的关系[J].局解手术学杂志,2024,33(10):863-866.
SONG Chun-guang,NIU Zhi-xin,HE Feng,et al.Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(10):863-866.
宋春光,牛志新,何峰等.结肠癌组织TLR4、CHI3L1表达与根治术后预后的关系[J].局解手术学杂志,2024,33(10):863-866. DOI： 10.11659/jjssx.10E023038.
SONG Chun-guang,NIU Zhi-xin,HE Feng,et al.Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(10):863-866. DOI： 10.11659/jjssx.10E023038.
摘要
目的
2
探讨结肠癌组织中Toll样受体4（TLR4）、壳多糖酶3样蛋白1（CHI3L1）的表达及其与患者根治术后预后的关系。
方法
2
选取2017年1月至2018年5月于我院行结肠癌根治术的152例患者为研究对象，根据患者术后5年生存情况分为预后良好组（
n
=97）和预后不良组（
n
=47）。采用免疫组织化学染色法检测结肠癌组织及癌旁组织中TLR4、CHI3L1的表达水平；分析结肠癌组织中TLR4和CHI3L1表达与患者预后的关系，并分析结肠癌患者预后的影响因素。
结果
2
结肠癌组织中TLR4和CHI3L1阳性表达率显著高于癌旁组织（
P
<
0.05）。结肠癌组织中TLR4表达与患者肿瘤分化程度、临床分期和淋巴结转移有关（
P
<
0.05），CHI3L1表达与结肠癌患者肿瘤直径、肿瘤分化程度、临床分期和淋巴结转移有关（
P
<
0.05）。与预后良好组比较，预后不良组患者肿瘤低分化、临床分期Ⅲ期、淋巴结转移、TLR4阳性表达和CHI3L1阳性表达的占比较高（
P
<
0.05）。TLR4阳性表达患者5年生存率为60.38%，低于TLR4阴性表达患者的86.84%（
χ
2
=9.104，
P
<
0.05）；CHI3L1阳性表达患者5年生存率为58.06%，低于CHI3L1阴性表达患者的84.31%（
χ
2
=10.935，
P
<
0.05）。TLR4阳性、CHI3L1阳性、肿瘤低分化、临床分期Ⅲ期、淋巴结转移是结肠癌患者预后的独立危险因素（
P
<
0.05）。
结论
2
TLR4和CHI3L1与结肠癌的发生和临床病理特征有关，且结肠癌组织中TLR4和CHI3L1阳性表达不利于患者预后，二者有望成为临床治疗靶点。
Abstract
Objective
2
To investigate the correlation between the expression of Toll-like receptor 4 （TLR4） and chitosanase 3-like protein 1 （CHI3L1） in colon cancer tissue and the prognosis of patients after radical surgery.
Methods
2
A total of 152 patients who underwent radical colon cancer surgery in our hospital from January 2017 to May 2018 were collected and divided into the good prognosis group （
n
=97） and the poor prognosis group （
n
=47） according to the 5-year survival status after surgery. Immunohistochemical staining was applied to detect the expression levels of TLR4 and CHI3L1 in colon cancer tissues and adjacent tissues； the correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis of patients was analyzed，and the influencing factors for prognosis of colon cancer patients were analyzed.
Results
2
The positive expression rates of TLR4 and CHI3L1 in colon cancer tissues were obviously higher than those in adjacent tissues （
P
<
0.05）. The expression of TLR4 in colon cancer tissue was related to the degree of tumor differentiation，clinical staging，and lymph node metastasis of colon cancer patients （
P
<
0.05），the expression of CHI3L1 was related to the tumor diameter，degree of tumor differentiation，clin
ical staging，and lymph node metastasis of colon cancer patients （
P
<
0.05）. Compared with the good prognosis group，the poor prognosis group had higher proportions of patients with poorly differentiated tumor，clinical stageⅢ，lymph node metastasis，and positive expression of TLR4 and CHI3L1 （
P
<
0.05）. The 5-year survival rate of patient with TLR4 positive expression was 60.38%，which was lower than that of 86.84% of patients with TLR4 negative expression （
χ
2
=9.104，
P
<
0.05）； the 5-year survival rate of patients with CHI3L1 positive expression was 58.06%，which was lower than that of 84.31% of patients with CHI3L1 negative expression （
χ
2
=10.935，
P
<
0.05）. The positive expression of TLR4 and CHI3L1，poorly differentiated tumor，clinical stage Ⅲ，and lymph node metastasis were the independent risk factors for the prognosis of colon cancer patients （
P
<
0.05）.
Conclusion
2
TLR4 and CHI3L1 are related to the occurrence and clinicopathological features of colon cancer，and the positive expression of TLR4 and CHI3L1 in colon cancer tissues is not conducive to the prognosis of patients，so both of them are expected to become clinical treatment targets.
关键词
结肠癌根治术预后Toll样受体4壳多糖酶3样蛋白1
Keywords
colon cancerradical surgeryprognosisToll-like receptor 4chitinase 3-like protein 1
references
Kim SH，Song SE，Baik H，et al. 15-Prostaglandin dehydrogenase inhibition enhances colon cancer metastasis by up-regulation of epithelial-to-mesenchymal transition genes［J］.Anticancer Res，2022，42（11）：5385-5396.doi：10.21873/anticanres.16043http://dx.doi.org/10.21873/anticanres.16043.
Kato I，Sun J. Microbiome and diet in colon cancer development and treatment［J］.Cancer J，2023，29（2）：89-97.doi：10.1097/PPO.0000000000000649http://dx.doi.org/10.1097/PPO.0000000000000649.
曹强坚，黎小爱，吴宝安. 结肠癌中USP22表达水平与基质金属蛋白酶及预后的相关性［J］. 临床和实验医学杂志，2022，21（10）：1045-1048. doi： 10.3969/j.issn.1671-4695.2022.10.010http://dx.doi.org/10.3969/j.issn.1671-4695.2022.10.010.
Verkuijl SJ，Jonker JE，Trzpis M，et al.Functional outcomes of surgery for colon cancer： a systematic review and meta-analysis［J］. Eur J Surg Oncol，2021，47（5）：960-969.doi：10.1016/j.ejso.2020.11.136http://dx.doi.org/10.1016/j.ejso.2020.11.136.
孙跃明.结直肠癌外科治疗进展［J］.中华消化外科杂志，2024，23（6）： 789-794. doi： 10.3760/cma.j.cn115610-20240508-24243http://dx.doi.org/10.3760/cma.j.cn115610-20240508-24243.
Kong C，Yan X，Zhu Y，et al. Fusobacterium nucleatum promotes the development of colorectal cancer by activating a cytochrome P450/Epoxyoctadecenoic acid axis via TLR4/Keap1/NRF2 signaling［J］. Cancer Res，2021，81（17）：4485-4498. doi： 10.1158/0008-5472.CAN-21-0453http://dx.doi.org/10.1158/0008-5472.CAN-21-0453.
Zhao T，Su Z，Li Y，et al. Chitinase-3 like-protein-1 function and its role in diseases［J］. Signal Transduct Target Ther，2020，5（1）：201-220. doi： 10.1038/s41392-020-00303-7http://dx.doi.org/10.1038/s41392-020-00303-7.
Gao Y，Han T，Han C，et al. Propofol regulates the TLR4/NF-κB pathway through miRNA-155 to protect colorectal cancer intestinal barrier［J］. Inflammation，2021，44（5）：2078-2090. doi： 10.1007/s10753-021-01485-0http://dx.doi.org/10.1007/s10753-021-01485-0.
中华人民共和国卫生和计划生育委员会医政医管局，中华医学会肿瘤学分会.中国结直肠癌诊疗规范（2017年版）［J］.中华外科杂志，2018，56（4）：241-258.doi：10.3760/cma.j.issn.0529-5815. 2018.04.001http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2018.04.001.
杨学丽，姜琳娜，安欣，等. miR-383和PRDX3在结肠癌组织中的表达水平及意义［J］. 国际检验医学杂志，2022，43（17）：2125-2130. doi： 10.3969/j.issn.1673-4130.2022.17.016http://dx.doi.org/10.3969/j.issn.1673-4130.2022.17.016.
Arredondo J，Pastor E，Simó V，et al. Neoadjuvant chemotherapy in locally advanced colon cancer： a systematic review［J］. Tech Coloproctol，2020，24（10）：1001-1015. doi： 10.1007/s10151-020-02289-4http://dx.doi.org/10.1007/s10151-020-02289-4.
Sangwan V，Al-Marzouki L，Pal S，et al. Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis［J］. Clin Exp Metastasis，2022，39（2）：323-333. doi： 10.1007/s10585-021-10133-8http://dx.doi.org/10.1007/s10585-021-10133-8.
Zandi Z， Kashani B， Bashash D， et al. The anticancer effect of the TLR4 inhibition using TAK-242 （resatorvid） either as a single agent or in combination with chemotherapy： a novel therapeutic potential for breast cancer［J］. J Cell Biochem， 2020， 121（2）：1623-1634. doi： 10.1002/jcb.29397http://dx.doi.org/10.1002/jcb.29397.
陈炜， 许正国， 杨永志. Toll样受体2和Toll样受体4在结直肠癌组织中的表达及其意义［J］.中国卫生检验杂志，2021，31（13）：1589-1592.
Jin BR，Chung KS，Hwang S，et al. Rosmarinic acid represses colitis-associated colon cancer： a pivotal involvement of the TLR4-mediated NF-κB-STAT3 axis［J］.Neoplasia，2021，23（6）：561-573.doi： 10.1016/j.neo.2021.05.002http://dx.doi.org/10.1016/j.neo.2021.05.002.
李博文， 韩元圣， 黄高俊， 等. 微小RNA-370-3p和Toll样受体4在结直肠癌组织中的表达及临床意义［J］. 临床外科杂志， 2022， 30（9）：860-864. doi： 10.3969/j.issn.1005-6483.2022.09.016http://dx.doi.org/10.3969/j.issn.1005-6483.2022.09.016.
Huang J，Gu Z，Xu Y，et al.CHI3L1 （Chitinase 3 like 1） upregulation is associated with macrophage signatures in esophageal cancer［J］.Bioengineered，2021，12（1）：7882-7892.doi：10.1080/21655979.2021.1974654http://dx.doi.org/10.1080/21655979.2021.1974654.
敬文娜， 朱峥燕. 宫颈癌组织中CHI3L1、NRIP1蛋白及LCoR的表达与临床病理特征、预后的相关性［J］. 实用癌症杂志， 2022， 37（11）：1767-1770. doi： 10.3969/j.issn.1001-5930.2022.11.007http://dx.doi.org/10.3969/j.issn.1001-5930.2022.11.007.
Hao H， Chen H， Xie L， et al. LncRNA KCNQ1OT1 promotes proliferation， invasion and metastasis of prostate cancer by regulating miR-211-5p/CHI3L1 pathway［J］. Onco Targets Ther， 2021， 14（1）：1659-1671. doi： 10.2147/OTT.S288785http://dx.doi.org/10.2147/OTT.S288785.
Zhao T， Zeng J， Xu Y， et al. Chitinase-3 like-protein-1 promotes glioma progression via the NF-κB signaling pathway and tumor microenvironment reprogramming［J］. Theranostics， 2022， 12（16）：6989-7008. doi： 10.7150/thno.75069http://dx.doi.org/10.7150/thno.75069.
彭洪， 吴洪， 唐军伟， 等. CHI3L1通过KLF6介导的Warburg效应促进结直肠癌细胞增殖和侵袭［J］. 川北医学院学报， 2022， 37（2）：137-142. doi： 10.3969/j.issn.1005-3697.2022.02.001http://dx.doi.org/10.3969/j.issn.1005-3697.2022.02.001.
0
浏览量
0
下载量
0
CSCD
- 网络PDF下载
- WORD下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
